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Mycopathologia

, 166:319 | Cite as

Strain Differentiation of Dermatophytes

  • Susan M. Abdel-Rahman
Article

Abstract

As molecular-based investigations begin to uncover the large degree of genetic variation that can exist within dermatophyte species, and population-based studies reveal exceedingly high rates of endemicity for these organisms, species typing has become inadequate to gain insight into these pathogens and the nature of the infections that they cause. This review examines studies that have applied strain typing strategies to explore intra-specific genetic diversity among the dermatophytes in attempts to address a number of relevant clinico-epidemiologic questions about these common fungal pathogens.

Keywords

Trichophyton Microsporum Tinea Epidemiology Evolution Population studies 

Abbreviations

RAPD

Randomly amplified polymorphic DNA

AP-PCR

Arbitrarily primed polymerase chain reaction

RAMD

Randomly amplified monomorphic DNA

SSCP

Single-stranded conformational polymorphism

AFLP

Amplified fragment length polymorphism

RFLP

Restriction fragment length polymorphism

VNTR

Variable number tandem repeats

ITS

Internal transcribed spacer

NTS

Non-transcribed spacer

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Division of Pediatric Clinical PharmacologyThe Children’s Mercy Hospitals and ClinicsKansas CityUSA
  2. 2.Department of PediatricsUniversity of Missouri-Kansas City, School of MedicineKansas CityUSA

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