, Volume 164, Issue 5, pp 217–224 | Cite as

The effect of vaginal candidiasis on the levels of the oxidative biomarkers in plasma and tissue samples of diabetic rats

  • Semra Kustimur
  • Ayse Kalkanci
  • Gonca Akbulut
  • Bilge Gonul
  • Emre Bulduk
  • F. Nur Aksakal
  • Ilhan Yetkin


The aim of this study is to determine the relation between diabetes and vaginal candidiasis in terms of oxidative biomarker levels in a vaginal candidiasis model of the diabetic rats by evaluating malondialdehyde (MDA), sulphydrile groups or glutathione (RSH), and ascorbic acid (C vit) levels. All rats were randomly divided into five groups. All of the groups were observed for 21 days. In the treated diabetes groups, MDA (0.90, 0.68 nmol/ml and 3.78, 3.79 nmol/g tissue, plasma and vaginal tissue, respectively) and RSH (227, 171 nmol/100 ml 0.38, 0.37 µmol/g tissue, plasma and vaginal tissue, respectively) levels were found to be decreased while the levels of C vit were found to be increased (0.49, 0.37 µmol/l 2.39, 2.01 nmol/g tissue plasma, and vaginal tissue, respectively) (P < 0.05). In the groups of untreated diabetes, vaginal candidiasis were found to be more serious and oxidative biomarkers were found to be increased (MDA 1.30, 1.26 nmol/ml and 7.82, 2.37 nmol/g tissue and RSH 258, 145 nmol/100 ml and 0.31, 0.46 µmol/g tissue) while the antioxidant C vit levels were found to be decreased (0.24, 0.17 µmol/l 1.33, 2.66 nmol/g tissue) (P < 0.05). RSH, plasma MDA, blood glucose, and tissue MDA levels of vaginal candidiasis embedeled diabetic rats, were found to be higher than those in untreated diabetic and untreated vaginitis enbedeled rats ‹P < 0.05’. Vaginal candidiasis caused oxidative stress in diabetic rats working together. Systemic oxidative stress biomarkers were found to be affected from vaginal candidiasis although it was a local mucosal infection.


Diabetes Vaginal candidiasis Malondialdehyde Glutathione Ascorbic acid 


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This study was conducted with the financial support of Gazi University Scientific Research Council, project number: 01/2002-96.


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Semra Kustimur
    • 1
  • Ayse Kalkanci
    • 1
  • Gonca Akbulut
    • 2
  • Bilge Gonul
    • 2
  • Emre Bulduk
    • 2
  • F. Nur Aksakal
    • 3
  • Ilhan Yetkin
    • 4
  1. 1.Department of Microbiology, Faculty of MedicineGazi UniversityBesevlerTurkey
  2. 2.Department of Physiology, Faculty of MedicineGazi UniversityBesevlerTurkey
  3. 3.Department of Public Health, Faculty of MedicineGazi UniversityBesevlerTurkey
  4. 4.Department of Endocrinology, Faculty of MedicineGazi UniversityBesevlerTurkey

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