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Mycopathologia

, Volume 161, Issue 3, pp 147–152 | Cite as

Effect of Azoles on the Secretion of a Candida albicans Metallopeptidase

  • Christine Imbert
  • Sabrina Imbert-Bouyer
  • Catherine Kauffmann-Lacroix
  • Gyslaine Daniault
  • Marie-Hélène Rodier
Article

Abstract

Azole antifungals act by inhibiting the activity of a lanosterol demethylase involved in the generation of the ergosterol of the cellular membrane of fungi. These drugs could also have action on other yeast components, like secreted aspartyl proteases. We demonstrate in this study that the in vitro secretion of a metallopeptidase could be modified during the growth of Candida albicans with subinhibitory concentrations of some azoles. Eight isolates of this yeast have been cultivated in presence of MIC, MIC/2 and MIC/4 of voriconazole, fluconazole and itraconazole. The presence of voriconazole and fluconazole decreased the secretion of the metallopeptidase in the culture medium, whereas itraconazole increased this secretion for three isolates. This study points to the fact that some antifungals, given in prophylaxis, could act in an unfavourable way on some potential factors of pathogenicity.

Keywords

Azoles C. albicans chemoprophylaxis metallopeptidase 

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Copyright information

© Springer 2006

Authors and Affiliations

  • Christine Imbert
    • 1
  • Sabrina Imbert-Bouyer
    • 1
  • Catherine Kauffmann-Lacroix
    • 1
  • Gyslaine Daniault
    • 1
  • Marie-Hélène Rodier
    • 1
  1. 1.Laboratoire de parasitologie et mycologie médicalesUnité de recherche en biologie parasitaire et fongiquePoitiers CedexFrance

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