Emerging role of long non-coding RNAs in cancer chemoresistance: unravelling the multifaceted role and prospective therapeutic targeting

Abstract

Chemotherapy is one of the important treatment modules in early as well as advanced stages of cancer. However, the major limitation of chemotherapy is the development of chemoresistance in the transformed cells of cancer patients, which leads to cancer recurrence. Long non-coding RNAs (lncRNA) are the transcripts longer than 200 nucleotides in length, which are reported to associate with the initiation, progression, recurrence, and metastasis of different cancers. Several lncRNAs have been implicated in the prevalence of chemoresistant phenotypes and also in the restoration of drug sensitivity in chemoresistant cells. LncRNAs such as HOTAIR, H19, and a lot more are involved in the chemoresistance of cancer cells. Therefore, targeting the lncRNAs may serve as a novel strategy for treating chemoresistant cancer. This review throws light on the role of lncRNA in chemoresistance along with the perspective of the therapeutic targets for the treatment of multiple cancers.

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Acknowledgements

We apologize to the eminent researches working in this field whose work has not been cited due to space limitations. The authors are thankful to the Chairman, Department of Zoology, Aligarh Muslim University for his necessary help. DS and MAK express their gratitude to the Council of Scientific and Industrial Research, New Delhi for fellowship.

Funding

This study was funded by the University Grants Commission [F.30-377/2017(BSR)], Department of Science and Technology, Government of India) [EMR/2017/001758] and Council of Scientific and Industrial Research, India [524/(CSIR-UGC-NET) June 2019].

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Singh, D., Khan, M.A. & Siddique, H.R. Emerging role of long non-coding RNAs in cancer chemoresistance: unravelling the multifaceted role and prospective therapeutic targeting. Mol Biol Rep (2020). https://doi.org/10.1007/s11033-020-05609-x

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Keywords

  • LncRNA
  • Cancer
  • Chemoresistance
  • Signalling pathways
  • Therapeutic challenges