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The role of molecular mechanism of Ten-Eleven Translocation2 (TET2) family proteins in pathogenesis of cardiovascular diseases (CVDs)

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Abstract

Cardiovascular disease (CVD) is one of the most common diseases worldwide. The underlying pathogenesis of the disease has not yet been determined, but many factors have been identified. Tet methylcytosine dioxygenase 2 (TET2) is one of the epigenetic factors involved in regulating many genes. Therefore, based on the studies shown, this factor plays an important role in preventing the occurrence of CVD. TET2 has been shown to increase angiogenesis by expressing Robo4. It also increases the activity of Matrix metalloproteinases (MMPs) and stimulates the secretion of Vascular endothelial growth factor angiogenesis. On the other hand, it has been shown that TET2 regulates the expression of several genes and the development of the heart during the embryonic period due to its oxygenating role. TET2 has been shown to regulates the expression of the genes such as Ying Yang1 (YY1), Sox9b, Inhbaa and many other genes that ultimately lead to the differentiation of cardiomyocytes. On the other hand, it has been shown that some Long non coding RNA and MicroRNAs reduce TET2 expression and CVD. Finally, it is concluded that inducing TET2 expression can be a good therapeutic strategy to prevent or improve CVD.

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Acknowledgements

We wish to thank all our colleagues in Golestan Hospital and Allied Health Sciences School, Ahvaz Jundishapur University of Medical Sciences.

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Authors and Affiliations

  1. Department of Cardiac Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fatemeh Javaherforoosh Zadeh

  2. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fatemeh Javaherforoosh Zadeh

  3. Khuzestan Heart Association, Apadana Hospital, Ahvaz, Iran

    Tooba Akbari

  4. Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Zeynab Deris zayeri & Nader Davari

  5. Legal Medicine Research Center, Legal Medicine Organization, Legal Medicine Office of Khuzestan, Khuzestan, Iran

    Azin Samimi

  6. High Institute for Education and Research in Transfusion Medicine, Tehran, Iran

    Hadi Rezaeeyan

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  1. Fatemeh Javaherforoosh Zadeh
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  2. Tooba Akbari
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  3. Zeynab Deris zayeri
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HR has conceived the manuscript and revised it. FJZ, and AS wrote the manuscript. ZD and ND design table and figure. TA conduct revise and edited grammar English.

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Correspondence to Hadi Rezaeeyan.

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Zadeh, F.J., Akbari, T., zayeri, Z.D. et al. The role of molecular mechanism of Ten-Eleven Translocation2 (TET2) family proteins in pathogenesis of cardiovascular diseases (CVDs). Mol Biol Rep 47, 5503–5509 (2020). https://doi.org/10.1007/s11033-020-05602-4

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