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Chemokine gene polymorphisms association with increased risk of type 2 diabetes mellitus in Tatar ethnic group, Russia

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Abstract

Recent studies have shown that chemokines play an important role in the development of chronic inflammation in adipose tissue, obesity pathogenesis, glucose intolerance and type 2 diabetes. It has also been revealed that some SNPs in chemokine genes are associated with obesity, insulin resistance, type 2 diabetes and diabetes complications in different ethnic groups. The aim of this study was to determine the associations between SNPs in chemokine genes and type 2 diabetes in participants of Tatar ethnic group, living in Bashkortostan. Case–control and cross-sectional study were included in our study design. Five SNPs were genotyped in 440 type 2 diabetes (160 men and 280 women), 58.8 ± 9.2 years old (mean ± SD), BMI 29.3 ± 3.9 kg/m2 (mean ± SD) patients of Tatar ethnicity, and a control group of 500 Tatars (180 men and 320 women), 55.2 ± 11.6 years old (mean ± SD), BMI 25.9 ± 4.3 kg/m2 (mean ± SD). The SNPs rs6749704 in CCL20 [odds ratio (OR) = 2.77 (95% CI 1.81–4.25), р = 0.0001], rs2107538 in CCL5 [odds ratio (OR) = 1.80 (95% CI 1.46–2.22), p = 0.0001] were significantly associated with type 2 diabetes. Regression analysis revealed that rs1696941 in CCL11 was associated with the onset age and duration of type 2 diabetes as well as with HbA1c level (p = 0.034, p = 0.036 and p = 0.0054, respectively). The SNPs rs223828 in CCL17 and rs6749704 in CCL20 were correlated with obesity as estimated by BMI (p = 0.0004, p = 0.029, respectively). Rs223828 in CCL17 revealed the association with postprandial glucose level (p = 0.024) and HbA1c (p = 0.008). These data demonstrate that variants of chemokine genes are associated with type 2 diabetes and obesity of Tatar ethnic group inhabiting Bashkortostan Republic. Novel associations of the polymorphic loci in CCL20 (rs6749704) and CCL5 (rs2107538) genes with type 2 diabetes had been identified as a result of the conducted research.

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Abbreviations

AIC:

Akaike information criterion

T2D:

Type 2 diabetes

ICAM:

Intercellular adhesion molecule 1

CCL2 :

Gene of chemokine C–C motif ligand 2

CCL5 :

Gene of chemokine C–C motif ligand 5

CCL11 :

Gene of chemokine C–C motif ligand 11

CCL17 :

Gene of chemokine C–C motif ligand 17

CCL20 :

Gene of chemokine C–C motif ligand 20

CCL:

Chemokine C–C motif ligand

CCR:

Chemokine receptor

F:

Forward

R:

Reverse

RANTES:

Regulated on activation, normal T cell expressed and secreted

TLR:

Toll-like receptor

VCAM:

Vascular cell adhesion molecule

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Acknowledgements

The study was supported by Russian Foundation for Basic Research (Grant No. 18-015-00050) and Federal Agency for Scientific Organizations, bioresource collection support program.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Science, 71 October Ave., Ufa, Russia, 450054

    Olga V. Kochetova & Olga E. Mustafina

  2. Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of Healthcare Ministry of the Russian Federation, 3 Lenin St., Ufa, Russia, 45008

    Diana S. Avzaletdinova & Tatyana V. Morugova

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  1. Olga V. Kochetova
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  2. Diana S. Avzaletdinova
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  3. Tatyana V. Morugova
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Contributions

TVM: conceptualization; DSA: data curation; OEM: formal analysis; TVM: funding acquisition; OVK and DSA: investigation; OVK: methodology; OEM: project administration; TVM: supervision; OEM: validation; OVK: writing—original draft; DSA: writing—review and editing.

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Correspondence to Diana S. Avzaletdinova.

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Kochetova, O.V., Avzaletdinova, D.S., Morugova, T.V. et al. Chemokine gene polymorphisms association with increased risk of type 2 diabetes mellitus in Tatar ethnic group, Russia. Mol Biol Rep 46, 887–896 (2019). https://doi.org/10.1007/s11033-018-4544-6

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