Functions of RNA N6-methyladenosine modification in cancer progression

Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

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Acknowledgements

We thank the PubMed database and its contributors for this valuable public data set. We also thank Dr Menglong Zhao from Dutch Institute for Fundamental Energy Research for helping to edit this manuscript.

Funding

This work was supported by the Key Project of Scientific Research Foundation for Colleges and Universities in Henan Province (16A320081) and The National Natural Science Foundation of China (81802325).

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All authors participated in the preparation of the manuscript, read and approved the final manuscript.

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Correspondence to Feng Xu.

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Chen, B., Li, Y., Song, R. et al. Functions of RNA N6-methyladenosine modification in cancer progression. Mol Biol Rep 46, 1383–1391 (2019). https://doi.org/10.1007/s11033-018-4471-6

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Keywords

  • RNA N6-methyladenosine modification
  • Cancer progression
  • Physiological and pathological processes
  • Detection approaches
  • Clinical application