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Molecular Biology Reports

, Volume 46, Issue 1, pp 5–5 | Cite as

Comment on “Estrogen receptor alpha (ERS1) SNPs c454-397T>C (PvuII) and c454-351A>G (XbaI) are risk biomarkers for breast cancer development”

  • Bei WangEmail author
  • Fenlai Yuan
Letter to the Editor
  • 641 Downloads

To the Editors,

Recently, We read an article named “Estrogen receptor alpha (ERS1) SNPs c454-397T>C (PvuII) and c454-351A>G (XbaI) are risk biomarkers for breast cancer development” with huge interests and it was published online in Mol Biol Rep [1]. This paper written by Madeira et al. pointed out that no statistically significant associations were found between XbaI polymorphism and the risk of breast cancer.

Madeira’s work was amazing. However, after reviewing the data reported by Madeira et al., we find a key issue that is noticeable and worth mentioning. According to Madeira’s data, we were aware that the control groups of XbaI deviated from HWE (P < 0.05), because of which an unpersuasive conclusion was drawn about the link between XbaI polymorphism and the risk of breast cancer.

Up to now, extensive researches have been carried out to investigate the relations between XbaI polymorphism and the risk of breast cancer. Anyway, previous conclusions were inconsistent [2, 3], which might be caused by the small sample size. Meanwhile, different inclusion and exclusion criteria should also be taken into considerations. In summary, the conclusions drawn by Madeira should be interpreted with caution. In the coming future, massive and rigorous studies will still be needed so that associations between XbaI polymorphism and the risk of breast cancer can be better assessed.

Notes

Compliance with ethical standards

Conflict of interest

All the authors declare no conflict of interest.

References

  1. 1.
    Madeira KP, Daltoe RD, Sirtoli GM, Carvalho AA, Rangel LB, Silva IV (2014) Estrogen receptor alpha (ERS1) SNPs c454-397T>C (PvuII) and c454-351A>G (XbaI) are risk biomarkers for breast cancer development. Mol Biol Rep 41(8):5459–5466.  https://doi.org/10.1007/s11033-014-3419-8 CrossRefPubMedGoogle Scholar
  2. 2.
    Lu H, Chen D, Hu LP, Zhou LL, Xu HY, Bai YH, Lin XY (2014) Estrogen receptor alpha gene polymorphisms and breast cancer risk: a case-control study with meta-analysis combined. Asian Pac J Cancer Prev 14(11):6743–6749CrossRefPubMedGoogle Scholar
  3. 3.
    Li LW, Xu L (2012) Menopausal status modifies breast cancer risk associated with ESR1 PvuII and XbaI polymorphisms in Asian women: a HuGE review and meta-analysis. Asian Pac J Cancer Prev 13(10):5105–5111CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Central LaboratoryThird Hospital Affiliated to Nantong UniversityWuxiChina

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