Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment
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Adiponectin is a protein hormone secreted exclusively by adipocytes and it is responsible for insulin sensitization in the human body. Deregulation of adiponectin and its downstream signaling pathway genes have been found to be involved in the gastric cancer carcinogenesis; however, whether the variants on adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) affect the prognosis of gastric cancer patients are still unknown. Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients. No significant association between the four variants and the overall survival of the gastric cancer patients was found. However, for those patients without a previous history of alcohol drinking, the rs266729 GG/CG genotype carriers showed a significantly decreased gastric cancer mortality compared to homogeneity CC patients (HR 0.74, 95 % CI 0.56–0.97; p = 0.032) after adjustment for variants age, sex, smoking status, tumor stage, tumor location and post-surgery chemotherapy. No significant association between the variant rs266729 genotypes and overall survival for the gastric cancer patients with an alcohol drinking habit. These data suggested that the variant rs266729 was an independent prognostic factor for the never drinking gastric cancer patients who received surgical treatment.
KeywordsAdiponectin Adiponectin receptor 1 Gastric cancer Overall survival
Single nucleotide polymorphisms
Adiponectin receptor 1 gene
- 95 % CI
95 % confidence interval
AMP-activated protein kinase
Peroxisome proliferator-activated receptor
Non-small cell lung cancer
Fibroblast growth factor
Platelet-derived growth factor BB
- HB EGF
Heparin-binding epidermal growth factor-like growth factor
This study was supported by grants from the Ministry of Science and Technology of China (2012BAK01B00 and 2014AA020524), the National Nature Science Foundation (81125020, 81328022, 81302507 and 81302809), the Key Research Program KSZD-EW-Z-021 and KSZD-EW-Z-019 of the Chinese Academy of Sciences, the Science and Technology Commission of Shanghai Municipality (12431900500), the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences(2012KIP308 and 2012KIP515) and the Food Safety Research Center and Key Laboratory of Food Safety Research of INS, SIBS, CAS.
Conflict of interest
None of the authors for the manuscript has declared any conflict of interest.
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