Molecular Biology Reports

, Volume 42, Issue 2, pp 355–361 | Cite as

Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment

  • Xuming Wu
  • Peizhan Chen
  • Yiyi Ou
  • Jibin Liu
  • Chenglin Li
  • Hui Wang
  • Fulin Qiang


Adiponectin is a protein hormone secreted exclusively by adipocytes and it is responsible for insulin sensitization in the human body. Deregulation of adiponectin and its downstream signaling pathway genes have been found to be involved in the gastric cancer carcinogenesis; however, whether the variants on adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) affect the prognosis of gastric cancer patients are still unknown. Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients. No significant association between the four variants and the overall survival of the gastric cancer patients was found. However, for those patients without a previous history of alcohol drinking, the rs266729 GG/CG genotype carriers showed a significantly decreased gastric cancer mortality compared to homogeneity CC patients (HR 0.74, 95 % CI 0.56–0.97; p = 0.032) after adjustment for variants age, sex, smoking status, tumor stage, tumor location and post-surgery chemotherapy. No significant association between the variant rs266729 genotypes and overall survival for the gastric cancer patients with an alcohol drinking habit. These data suggested that the variant rs266729 was an independent prognostic factor for the never drinking gastric cancer patients who received surgical treatment.


Adiponectin Adiponectin receptor 1 Gastric cancer Overall survival 



Single nucleotide polymorphisms


Adiponectin gene


Adiponectin receptor 1 gene


Hazard ratio

95 % CI

95 % confidence interval


AMP-activated protein kinase


Peroxisome proliferator-activated receptor


Non-small cell lung cancer


Fibroblast growth factor


Platelet-derived growth factor BB


Heparin-binding epidermal growth factor-like growth factor



This study was supported by grants from the Ministry of Science and Technology of China (2012BAK01B00 and 2014AA020524), the National Nature Science Foundation (81125020, 81328022, 81302507 and 81302809), the Key Research Program KSZD-EW-Z-021 and KSZD-EW-Z-019 of the Chinese Academy of Sciences, the Science and Technology Commission of Shanghai Municipality (12431900500), the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences(2012KIP308 and 2012KIP515) and the Food Safety Research Center and Key Laboratory of Food Safety Research of INS, SIBS, CAS.

Conflict of interest

None of the authors for the manuscript has declared any conflict of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Nantong Tumor HospitalNantongPeople’s Republic of China
  2. 2.Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; School of Life Science and TechnologyShanghaiTech UniversityShanghaiPeople’s Republic of China
  3. 3.Key Laboratory of Food Safety Risk Assessment of Ministry of HealthChina National Center for Food Safety Risk AssessmentBeijingPeople’s Republic of China
  4. 4.Medical Department, the General Hospital of NavyBeijingPeople’s Republic of China

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