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RETRACTED ARTICLE: IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case–control studies

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This article was retracted on 18 August 2015

Abstract

This current meta-analysis of case–control studies was continued to investigate whether the genetic polymorphisms of IL-18 gene contribute to the occurrence and progression of tuberculosis (TB). We searched certain English and Chinese databases for relevant studies without language restrictions. Meta-analysis for the moment was performed with the adoption of the STATA statistical software. Crude OR and its corresponding 95 % confidence interval (95 % CI) were calculated as estimates of relative risk for UC under different genetic models. Seven case–control studies (TB patients = 1,325, healthy subjects = 1,778) were included for the following analysis. We evaluated two functional polymorphisms (rs1946518 C>A and rs187238 G>C). Pooled OR within the progression of statistical analysis indicated that the specific polymorphism of IL-18 rs1946518 C>A showed a closely relationship with the elevated susceptibility to TB under those three genetic models (allele model: OR 1.24, 95 % CI 1.11–1.38, P < 0.001; dominant model: OR 1.41, 95 % CI 1.21–1.65, P < 0.001; homozygous model: OR 1.46, 95 % CI 1.15–1.86, P = 0.002; respectively). However, we observed no statistical associations of the IL-18 rs187238 G>C polymorphism with the susceptibility to TB under any of the genetic models (all P > 0.05). Country-stratified analysis results detected that the variants of IL-18 may be strongly enrolled in the risk of TB among populations in China (allele model: OR 1.19, 95 % CI 1.06–1.33, P = 0.003; recessive model: OR 1.54, 95 % CI 1.00–2.36, P = 0.048; homozygous model: OR 1.59, 95 % CI 1.09–2.33, P = 0.016; respectively), but not among populations in Iran, Korea and India (all P > 0.05). Current results provide strong evidence that IL-18 mutations may be evidently related to the occurrence and development of TB, especially for the rs1946518 C>A polymorphism among populations in China.

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Acknowledgments

We would like to acknowledge the helpful comments on this paper received from our reviewers.

Conflict of interest

We declare that we have no conflicts of interest.

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Authors and Affiliations

  1. Department of Respiratory Medicine, The Fourth Affiliated Hospital of China Medical University, South Seven Road No. 102, Heping District, Shenyang, 110005, People’s Republic of China

    Xiao-Ling Yu, Fei Zhao, Jun Zhang & Xiao-Ming Pan

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  1. Xiao-Ling Yu
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  2. Fei Zhao
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Correspondence to Xiao-Ling Yu.

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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Yu, XL., Zhao, F., Zhang, J. et al. RETRACTED ARTICLE: IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case–control studies. Mol Biol Rep 41, 6013–6023 (2014). https://doi.org/10.1007/s11033-014-3479-9

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