Molecular Biology Reports

, Volume 41, Issue 7, pp 4713–4720 | Cite as

Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries

  • Ke-Qing Shi
  • Fa-Ling Wu
  • Wen-Yue Liu
  • Chen-Chen Zhao
  • Chang-Xi Chen
  • Yao-Yao Xie
  • Sheng-Jie Wu
  • Xian-Feng Lin
  • Yong-Ping Chen
  • Danny Ka-Ho Wong
  • Man-Fung Yuen
  • Ming-Hua Zheng


In-stent restenosis (ISR) remains the most common complication of percutaneous coronary intervention. Due to shared risk factors, it is postulated that non-alcoholic fatty liver disease (NAFLD) patients have an increased risk of ISR. This study aimed to determine the association between NAFLD and ISR in patients after bare metal stenting. This study included a cohort of 210 consecutive patients (150 men and 60 women) undergoing follow-up angiography. The primary end-point was angiographic ISR. Multivariate logistic regression analysis was used to identify independent risk factors for ISR. The cumulative ISR rate during follow-up was analyzed by Kaplan–Meier method. Subgroup analyses were also done for different gender. The ISR rate was 29.5 %. Patients with NAFLD had a significantly higher prevalence of ISR than patients without NAFLD (43.3 vs. 16.0 %, P < 0.001). In logistic regression analysis, NAFLD was associated with increased ISR, independent of low-density lipoprotein cholesterol, body mass index (adjusted odds ratio: 2.688, 95 % confidence intervals: 1.285–5.537, P < 0.001). Male NAFLD patients had a higher prevalence of ISR than patients without NAFLD (48.4 vs. 15.3 %, P < 0.001), while the prevalence of ISR in female patients with and without NAFLD were comparable (7.7 vs. 17.0 %, P = 0.404). Kaplan–Meier analysis showed a significant association between NAFLD and ISR in all patients (log-rank P = 0.008) and in male subgroup (log-rank P = 0.033), but not in female subgroup (log-rank P = 0.313). This preliminary study suggests that NAFLD could independently associate with a high prevalence of ISR, especially in male patients.


Non-alcoholic fatty liver disease In-stent restenosis Bare metal stent Angiography 



Body mass index


Confidence intervals


Cardiovascular disease


High density lipoprotein


In-stent restenosis


Low density lipoprotein


Non-alcoholic fatty liver disease


Odds ratios


Percutaneous coronary intervention



This work was supported by grants from the Scientific Research Foundation of Wenzhou, Zhejiang Province, China (H20090014, Y20090269), Health Bureau of Zhejiang Province (2010KYB070), Research Foundation of Education Bureau of Zhejiang Province (Y201009942), Fresh Talent Program for Science and Technology Department of Zhejiang Province (2013R413018, 2013R413035 and 2013R413015), Research Funds for Tian Qing Liver Diseases (TQGB20120057) and Project of New Century 551 Talent Nurturing in Wenzhou.

Conflict of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Ke-Qing Shi
    • 1
    • 2
  • Fa-Ling Wu
    • 1
    • 2
  • Wen-Yue Liu
    • 1
    • 3
  • Chen-Chen Zhao
    • 1
    • 3
  • Chang-Xi Chen
    • 4
  • Yao-Yao Xie
    • 5
  • Sheng-Jie Wu
    • 4
  • Xian-Feng Lin
    • 6
    • 1
  • Yong-Ping Chen
    • 1
    • 2
  • Danny Ka-Ho Wong
    • 7
  • Man-Fung Yuen
    • 7
    • 8
  • Ming-Hua Zheng
    • 1
    • 2
  1. 1.Department of Infection and Liver Diseases, Liver Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina
  2. 2.Institute of HepatologyWenzhou Medical UniversityWenzhouChina
  3. 3.School of the First Clinical Medical SciencesWenzhou Medical UniversityWenzhouChina
  4. 4.Department of CardiologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina
  5. 5.Department of Clinical LaboratoryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina
  6. 6.Department of Orthopaedic Surgery, Sir Run Run Shaw HospitalMedical College of Zhejiang UniversityHangzhouChina
  7. 7.Department of MedicineThe University of Hong Kong, Queen Mary HospitalHong KongChina
  8. 8.State Key Laboratory for Liver ResearchThe University of Hong Kong, Queen Mary HospitalHong KongChina

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