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Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries

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Abstract

In-stent restenosis (ISR) remains the most common complication of percutaneous coronary intervention. Due to shared risk factors, it is postulated that non-alcoholic fatty liver disease (NAFLD) patients have an increased risk of ISR. This study aimed to determine the association between NAFLD and ISR in patients after bare metal stenting. This study included a cohort of 210 consecutive patients (150 men and 60 women) undergoing follow-up angiography. The primary end-point was angiographic ISR. Multivariate logistic regression analysis was used to identify independent risk factors for ISR. The cumulative ISR rate during follow-up was analyzed by Kaplan–Meier method. Subgroup analyses were also done for different gender. The ISR rate was 29.5 %. Patients with NAFLD had a significantly higher prevalence of ISR than patients without NAFLD (43.3 vs. 16.0 %, P < 0.001). In logistic regression analysis, NAFLD was associated with increased ISR, independent of low-density lipoprotein cholesterol, body mass index (adjusted odds ratio: 2.688, 95 % confidence intervals: 1.285–5.537, P < 0.001). Male NAFLD patients had a higher prevalence of ISR than patients without NAFLD (48.4 vs. 15.3 %, P < 0.001), while the prevalence of ISR in female patients with and without NAFLD were comparable (7.7 vs. 17.0 %, P = 0.404). Kaplan–Meier analysis showed a significant association between NAFLD and ISR in all patients (log-rank P = 0.008) and in male subgroup (log-rank P = 0.033), but not in female subgroup (log-rank P = 0.313). This preliminary study suggests that NAFLD could independently associate with a high prevalence of ISR, especially in male patients.

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Abbreviations

BMI:

Body mass index

CI:

Confidence intervals

CVD:

Cardiovascular disease

HDL:

High density lipoprotein

ISR:

In-stent restenosis

LDL:

Low density lipoprotein

NAFLD:

Non-alcoholic fatty liver disease

OR:

Odds ratios

PCI:

Percutaneous coronary intervention

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Acknowledgments

This work was supported by grants from the Scientific Research Foundation of Wenzhou, Zhejiang Province, China (H20090014, Y20090269), Health Bureau of Zhejiang Province (2010KYB070), Research Foundation of Education Bureau of Zhejiang Province (Y201009942), Fresh Talent Program for Science and Technology Department of Zhejiang Province (2013R413018, 2013R413035 and 2013R413015), Research Funds for Tian Qing Liver Diseases (TQGB20120057) and Project of New Century 551 Talent Nurturing in Wenzhou.

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Authors and Affiliations

  1. Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Fuxue lane, Wenzhou, 325000, China

    Ke-Qing Shi, Fa-Ling Wu, Wen-Yue Liu, Chen-Chen Zhao, Xian-Feng Lin, Yong-Ping Chen & Ming-Hua Zheng

  2. Institute of Hepatology, Wenzhou Medical University, No. 2 Fuxue lane, Wenzhou, 325000, China

    Ke-Qing Shi, Fa-Ling Wu, Yong-Ping Chen & Ming-Hua Zheng

  3. School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China

    Wen-Yue Liu & Chen-Chen Zhao

  4. Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Chang-Xi Chen & Sheng-Jie Wu

  5. Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Yao-Yao Xie

  6. Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China

    Xian-Feng Lin

  7. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China

    Danny Ka-Ho Wong & Man-Fung Yuen

  8. State Key Laboratory for Liver Research, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China

    Man-Fung Yuen

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  1. Ke-Qing Shi
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  2. Fa-Ling Wu
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Correspondence to Ming-Hua Zheng.

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Shi, KQ., Wu, FL., Liu, WY. et al. Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries. Mol Biol Rep 41, 4713–4720 (2014). https://doi.org/10.1007/s11033-014-3342-z

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  • DOI: https://doi.org/10.1007/s11033-014-3342-z

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