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RETRACTED ARTICLE: Correlations of SELE genetic polymorphisms with risk of coronary heart disease and myocardial infarction: a meta-analysis

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This article was retracted on 18 August 2015

Abstract

This meta-analysis of case–control studies was conducted to determine whether SELE genetic polymorphisms contribute to the pathogenesis of coronary heart disease (CHD) and myocardial infarction (MI). The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Twenty case–control studies met the inclusion criteria, with a total of 2,292 CHD patients, 901 MI patients and 3,233 healthy controls. Six common polymorphisms in the SELE gene were evaluated, including 554L/F, 98G/T, 128S/R, 2692G/A, 1901C/T, and 1856A/G. The results of our meta-analysis suggest that SELE genetic polymorphisms might be strongly correlated with an increased risk of CHD (allele model: OR 2.08, 95 % CI 1.67–2.58, P < 0.001; dominant model: OR 2.12, 95 % CI 1.68–2.68, P < 0.001; respectively), especially the SELE 554L/F, 98G/T and 128S/R polymorphisms. Furthermore, our findings indicated that SELE genetic polymorphisms were closely linked to the risk of CHD in Asians but not Caucasians. However, our findings reveal no positive correlations between SELE genetic polymorphisms and MI risk (allele model: OR 1.39, 95 % CI 1.00–1.94, P = 0.054; dominant model: OR 1.40, 95 % CI 0.96–2.04, P = 0.081; respectively). The current meta-analysis suggests that SELE genetic polymorphisms may contribute to an increased risk of CHD, especially the SELE 554L/F, 98G/T and 128S/R polymorphisms in Asians. However, SELE genetic polymorphisms may not be important determinants of susceptibility to MI.

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References

  1. Tehrani DM, Seto AH (2013) Third universal definition of myocardial infarction: update, caveats, differential diagnoses. Cleve Clin J Med 80:777–786. doi:10.3949/ccjm.80a.12158

    Article  PubMed  Google Scholar 

  2. Chen J (2013) The frontiers of nuclear cardiology research. J Biomed Res 27:437–438. doi:10.7555/JBR.27.20130150

    Article  PubMed Central  PubMed  Google Scholar 

  3. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, Katus HA, Newby LK et al (2007) Universal definition of myocardial infarction. Circulation 116:2634–2653. doi:10.1161/CIRCULATIONAHA.107.187397

    Article  PubMed  Google Scholar 

  4. Goswami B, Rajappa M, Singh B, Ray PC, Kumar S, Mallika V (2010) Inflammation and dyslipidaemia: a possible interplay between established risk factors in north indian males with coronary artery disease. Cardiovasc J Afr 21:103–108. http://www.ncbi.nlm.nih.gov/pubmed/20532435

  5. Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ et al (2013) A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol 33:1427–1434. doi:10.1161/ATVBAHA.112.300112

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Vinukonda G, Shaik Mohammad N, Md Nurul Jain J, Prasad Chintakindi K, Rama Devi Akella R (2009) Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. Clin Chim Acta 405:127–131. doi:10.1016/j.cca.2009.04.015

    Article  CAS  PubMed  Google Scholar 

  7. Kivimaki M, Nyberg ST, Batty GD, Fransson EI, Heikkila K, Alfredsson L, Bjorner JB, Borritz M et al (2012) Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet 380:1491–1497. doi:10.1016/S0140-6736(12)60994-5

    Article  PubMed Central  PubMed  Google Scholar 

  8. Torpy JM, Burke AE, Glass RM (2009) Jama patient page. Coronary heart disease risk factors. JAMA 302:2388. doi:10.1001/jama.302.21.2388

    Article  PubMed  Google Scholar 

  9. Teo KK, Ounpuu S, Hawken S, Pandey MR, Valentin V, Hunt D, Diaz R, Rashed W et al (2006) Tobacco use and risk of myocardial infarction in 52 countries in the Interheart study: a case-control study. Lancet 368:647–658. doi:10.1016/S0140-6736(06)69249-0

    Article  PubMed  Google Scholar 

  10. Jubeli E, Moine L, Vergnaud-Gauduchon J, Barratt G (2012) E-selectin as a target for drug delivery and molecular imaging. J Control Release 158:194–206. doi:10.1016/j.jconrel.2011.09.084

    Article  CAS  PubMed  Google Scholar 

  11. Visvanathan S, Wagner C, Rojas J, Kay J, Dasgupta B, Matteson EL, Mack M, Baker DG et al (2009) E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy. J Rheumatol 36:1371–1379. doi:10.3899/jrheum.080755

    Article  CAS  PubMed  Google Scholar 

  12. Smadja DM, Mulliken JB, Bischoff J (2012) E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol 181:2239–2247. doi:10.1016/j.ajpath.2012.08.030

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Libby P (2012) Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 32:2045–2051. doi:10.1161/ATVBAHA.108.179705

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Swirski FK, Nahrendorf M (2013) Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 339:161–166. doi:10.1126/science.1230719

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Li X, Johnson KR, Bryant M, Elkahloun AG, Amar M, Remaley AT, De Silva R, Hallenbeck JM et al (2011) Intranasal delivery of E-selectin reduces atherosclerosis in apoe−/− mice. PLoS One 6:e20620. doi:10.1371/journal.pone.0020620

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. El-Mesallamy HO, Hamdy NM, Salman TM, Mahmoud S (2011) Adiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s). Minerva Endocrinol 36:163–170. http://www.ncbi.nlm.nih.gov/pubmed/22019747

    Google Scholar 

  17. Stepien E, Krawczyk S, Kapelak B, Sobczynski R, Stolinski J, Wypasek E, Undas A, Sadowski J (2011) Effect of the e-selectin gene polymorphism (S149R) on platelet activation and adverse events after coronary artery surgery. Arch Med Res 42:375–381. doi:10.1016/j.arcmed.2011.07.007

    Article  CAS  PubMed  Google Scholar 

  18. Barbaux SC, Blankenberg S, Rupprecht HJ, Francomme C, Bickel C, Hafner G, Nicaud V, Meyer J et al (2001) Association between p-selectin gene polymorphisms and soluble p-selectin levels and their relation to coronary artery disease. Arterioscler Thromb Vasc Biol 21:1668–1673. http://www.ncbi.nlm.nih.gov/pubmed/11597943

  19. Goracy J, Goracy I, Kaczmarczyk M, Parczewski M, Brykczynski M, Clark J, Safranow K, Ciechanowicz A (2011) Low frequency haplotypes of e-selectin polymorphisms g2692a and c1901t give increased protection from coronary artery disease. Med Sci Monit 17:CR334–CR340

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Tripathi R, Singh PK, Tewari S, Tamhankar PM, Ramesh V, Agarwal S (2009) Genetic predisposition of e-selectin gene (s128r) polymorphism in patients with coronary artery disease (CAD). Indian J Med Res 130:423–427. http://www.ncbi.nlm.nih.gov/pubmed/19942746

    Google Scholar 

  21. Sakowicz A, Fendler W, Lelonek M, Pietrucha T (2010) Genetic variability and the risk of myocardial infarction in poles under 45 years of age. Arch Med Sci 6:160–167. doi:10.5114/aoms.2010.13887

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Endler G, Exner M, Raith M, Marculescu R, Mannhalter C, Endler L, Wojta J, Huber K et al (2003) The e-selectin S128R polymorphism is not a risk factor for coronary artery disease in patients with diabetes mellitus type 2. Thromb Res 112:47–50. doi:10.1016/j.thromres.2003.10.018

    Article  PubMed  Google Scholar 

  23. Stang A (2010) Critical evaluation of the newcastle-ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605. doi:10.1007/s10654-010-9491-z

    Article  PubMed  Google Scholar 

  24. Zintzaras E, Ioannidis JP (2005) Hegesma: genome search meta-analysis and heterogeneity testing. Bioinformatics 21:3672–3673. doi:10.1093/bioinformatics/bti536

    Article  CAS  PubMed  Google Scholar 

  25. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295:676–680. doi:10.1001/jama.295.6.676

    Article  CAS  PubMed  Google Scholar 

  26. Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N (2006) E-selectin S128R polymorphism and severe coronary artery disease in arabs. BMC Med Genet 7:52. doi:10.1186/1471-2350-7-52

    Article  PubMed Central  PubMed  Google Scholar 

  27. Zhang YL, Qin JJ (2013) Correlation of polymorphism E-selectin gene LEU554PHE with coronary heart disease. China J Mod Med 23:41–44

    Google Scholar 

  28. Hu HL, Cheng LX, Su FC, Yin XD, Wu TC (2006) Interaction of e-selectin s128r gene polymorphism and smoking on coronary heart disease. Acta Med Univ Sci Technol Huazhong 35:115–118

    CAS  Google Scholar 

  29. Li Y, Wei YS, Zhang PA, Wang M, Li XY, Huang CX (2004) Association of A561C polymorphism of the E-selectin with myocardial infarction and serum lipid levels in Chinese elderly. Chin J Geriatr 23:4–7

    CAS  Google Scholar 

  30. Lin F, Zhuang WT, Lin LX (2001) Association of E-selectin S128R gene polymorphism with coronary heart disease. J Fujian Med Univ 35:342–344

    Google Scholar 

  31. Lin F, Zhuang WT, Lin LX, Chen G (2003) Relationship between E selectin gene A561C polymorphism and type 2 diabetes mellitus complicated with coronary heart disease. J Clin Cardiol 19:531–532

    Google Scholar 

  32. Wei M, She HC, Li SJ, Lu YS (2007) Relationship between the level of serum e-selectin and ser128arg polymorphisms of e-selectin in patients with acute myocardial infarction. Chin J Emerg Med 16:1251–1254. doi:10.3760/j.issn:1671-0282.2007.12.005

    CAS  Google Scholar 

  33. Luo XY, Qi WH, Lu GP, He RM, Huang XY (2003) Association between E-selectin gene polymorphisms and coronary heart disease. Acta Univ Med Second Shanghai 23:220–222

    CAS  Google Scholar 

  34. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA et al (2006) Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation 114:I275–I281. doi:10.1161/circulationaha.105.001032

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  35. Wenzel K, Blackburn A, Ernst M, Affeldt M, Hanke R, Baumann G, Felix SB, Kleber FX et al (1997) Relationship of polymorphisms in the renin-angiotensin system and in E-selectin of patients with early severe coronary heart disease. J Mol Med (Berl) 75:57–61. http://link.springer.com/content/pdf/10.1007%2Fs001090050087.pdf

    Google Scholar 

  36. Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A (2003) E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. Arterioscler Thromb Vasc Biol 23:783–788. doi:10.1161/01.atv.0000067427.40133.59

    Article  CAS  PubMed  Google Scholar 

  37. Zak I, Sarecka B, Krauze J (2008) Synergistic effects between 561A > C and 98G > T polymorphisms of E-selectin gene and hypercholesterolemia in determining the susceptibility to coronary artery disease. Heart Vessels 23:257–263. doi:10.1007/s00380-008-1040-2

    Article  PubMed  Google Scholar 

  38. Zheng F, Chevalier JA, Zhang LQ, Virgil D, Ye SQ, Kwiterovich PO (2001) An HPHI polymorphism in the E-selectin gene is associated with premature coronary artery disease. Clin Genet 59:58–64. http://onlinelibrary.wiley.com/store/10.1034/j.1399-0004.2001.590110.x/asset/j.1399-0004.2001.590110.x.pdf?v=1&t=hoaq4pb0&s=46c8d8e0b1da2b9817cb5c3e49b56821978f1f15

  39. Ma H, Ma LY, Wang YM, Gao JX (2008) Association E-selectin gene polymorphisms with coronary heart disease in Gansu Ningxia Hui autonomous prefecture. Health Vocat Educ 26:135–137

    CAS  Google Scholar 

  40. Hong YD, Zhu HY, Chen YP, Wu H, MH H, Huang YS, Shi CJ (2009) Relationship of phlegm and blood-stasis syndrome in coronary heart disease with G98T and S128R polymorphism of E-selectin. J Guangdong Univ Tradit Chin Med 26:1–5. doi:10.3969/j.issn.1007-3213.2009.01.001

    CAS  Google Scholar 

  41. Li Y, Wei YS, Zhang PA, Wang M, Li XY, Huang CX (2004) The serum E-selectin level and the G98T and S128R polymorphisms of E-selectin in patients with acute myocardial infarction. Chin J Labor Med 27:51–54

    Google Scholar 

  42. Rao D, Jiang H, Zeng QT, Guo HP, Wang M, Li MH, Ge JB (2007) Correlation between e-selectin A128C gene polymorphism and coronary heart disease. Chin Heart J 19(547–549):555. doi:10.3969/j.issn.1009-7236.2007.05.014

    Google Scholar 

  43. Zhang YL, Peng WL, Tang TT (2011) Study of the relationship between polymorphisms of E-selectin gene +g98t in the exon 2 with coronary heart disease of han population in northern china. China J Mod Med 21:3515–3518, 3521. http://d.g.wanfangdata.com.cn/Periodical_zgxdyxzz201128015.aspx

  44. Kee F, Morrison C, Evans AE, McCrum E, McMaster D, Dallongeville J, Nicaud V, Poirier O et al (2000) Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Etude cas-temoin de l’infarctus myocarde. Heart 84:548–552. http://www.ncbi.nlm.nih.gov/pubmed/11040019

  45. Turhan H, Saydam GS, Erbay AR, Ayaz S, Yasar AS, Aksoy Y, Basar N, Yetkin E (2006) Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol 108:224–230. doi:10.1016/j.ijcard.2005.05.008

    Article  PubMed  Google Scholar 

  46. Semple JW, Italiano JE Jr, Freedman J (2011) Platelets and the immune continuum. Nat Rev Immunol 11:264–274. doi:10.1038/nri2956

    Article  CAS  PubMed  Google Scholar 

  47. Bendas G, Borsig L (2012) Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins. Int J Cell Biol 2012:676731. doi:10.1155/2012/676731

    Article  PubMed Central  PubMed  Google Scholar 

  48. Abu-Amero KK, Al-Mohanna F, Al-Boudari OM, Mohamed GH, Dzimiri N (2007) The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. BMC Med Genet 8:35. doi:10.1186/1471-2350-8-35

    Article  PubMed Central  PubMed  Google Scholar 

  49. Houshmand B, Rafiei A, Hajilooi M, Mani-Kashani K, Gholami L (2009) E-selectin and l-selectin polymorphisms in patients with periodontitis. J Periodontal Res 44:88–93. doi:10.1111/j.1600-0765.2008.01092.x

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We would like to acknowledge the helpful comments on this paper received from our reviewers.

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  1. Department of Cardiovascular Medicine, the Second Hospital of Shandong University, No. 247 Beiyuan Street, Tianqiao District, Jinan, 250033, People’s Republic of China

    Zhao-Qiang Dong, Xiang-Jun Wu & Qing-Hua Lu

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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Dong, ZQ., Wu, XJ. & Lu, QH. RETRACTED ARTICLE: Correlations of SELE genetic polymorphisms with risk of coronary heart disease and myocardial infarction: a meta-analysis. Mol Biol Rep 41, 3021–3031 (2014). https://doi.org/10.1007/s11033-014-3161-2

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