Molecular Biology Reports

, Volume 41, Issue 4, pp 2299–2306 | Cite as

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis

  • Peiliang Geng
  • Jie Yao
  • Yunfeng Zhu


The Ser326Cys polymorphism in the human 8-oxogunaine glycosylase (hOGG1) gene with lung cancer susceptibility had been investigated by the approaches of PCR–RFLP, PCR–SSCP and ASA. Due to limited specimen and different approaches the conclusion was drawn toughly. To evaluate this correlation comprehensively, a meta-analysis was performed based on 30 case–control studies, including 10,327 cases and 12,148 controls. The random-effects model was used to estimate the odds ratios and 95 % confidence interval for various contrasts of this polymorphism. The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models. Similarly, in the stratified analyses by ethnicity and source of control, no risk was observed between all the genetic models and lung cancer risk. Our meta-analysis revealed that there was little correlation between the hOGG1 Ser326Cys polymorphism and the risk of lung cancer.


Ser326Cys hOGG1 Polymorphism Susceptibility Lung cancer 



This project was supported by National High Technology Research and Development Program in China (2011AA02A110).


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.The Key LabCancer Center, Chinese PLA General HospitalBeijingPeople’s Republic of China
  2. 2.Department of OncologyPLA No. 161 Center HospitalWuhanPeople’s Republic of China
  3. 3.The College of Life Sciences and Bio-EngineeringBeijing Jiao-Tong UniversityBeijingPeople’s Republic of China

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