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Association of HSL gene E1-c.276C>T and E8-c.51C>T mutation with economical traits of Chinese Simmental cattle

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Abstract

Hormone-sensitive lipase (HSL) is responsible for the decomposition of triglycerides in adipose tissue to release free fatty acids, and it is a key rate-limiting enzyme in the regulation of adipose tissue deposition and decomposition. The objective of this study was to evaluate the association between novel SNPs in the coding region of bovine HSL gene and carcass and meat quality traits of Chinese Simmental-cross steers. Two novel SNPs were genotyped and the 47 traits of carcass and meat quality traits were measured in the population studied. Statistical analysis revealed that the SNPs of HSL gene were associated with the carcass and meat quality traits. The individuals with TT genotypes of E1-276C>T showed significant higher dressing percentage, net meat rate, hind legs circumference, fat coverage rate, mesenteric fat and kidney fat (p < 0.05). E8-51C>T (P17S) also showed a significant association with the pH of beef and fatty acids content in Chinese Simmental cattle (p < 0.01). Our findings indicated that polymorphisms in HSL might be one of important genetic factors that influence carcass yield and meat quality in beef cattle, and it may be a useful marker for meat quality traits in future marker-assisted selection programs in beef cattle breeding and production.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31000991), Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100061120039), Jilin Scientific and Technological Development Program (No. 20110229 and 20120226) and the National R&D. Project of Transgenic Organisms of Ministry of Science and Technology of China (2011ZX08007-001).

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Authors and Affiliations

  1. College of Animal Science, Jilin University, Xi An Road 5333, Changchun, 130062, Jilin, People’s Republic of China

    X. B. Fang, C. Y. Lu, Z. H. Zhao & R. J. Yang

  2. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Yuanmingyuan West Road No. 2 Haidian District, Beijing, 100193, People’s Republic of China

    L. P. Zhang & J. Y. Li

  3. College of Agriculture, Forestry and Life Sciences, Clemson University, Clemson, SC, 29634, USA

    X. Z. Yu

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  1. X. B. Fang
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Correspondence to Z. H. Zhao or R. J. Yang.

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X. B. Fang and L. P. Zhang have contributed equally to this study.

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Fang, X.B., Zhang, L.P., Yu, X.Z. et al. Association of HSL gene E1-c.276C>T and E8-c.51C>T mutation with economical traits of Chinese Simmental cattle. Mol Biol Rep 41, 105–112 (2014). https://doi.org/10.1007/s11033-013-2842-6

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  • DOI: https://doi.org/10.1007/s11033-013-2842-6

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