Molecular Biology Reports

, Volume 40, Issue 10, pp 6043–6051 | Cite as

Association between interferon gamma +874 T>A polymorphism and acute renal allograft rejection: evidence from published studies

  • Yu-Zheng Ge
  • Ran Wu
  • Rui-Peng Jia
  • Hao Liu
  • Peng Yu
  • Yan Zhao
  • Yu-Ming Feng


Interferon gamma is involved in the acute rejection (AR) episodes of transplant recipients. However, results from published studies on the association of interferon gamma (IFNG) +874 T>A (rs2430561) polymorphism with AR of renal allograft are conflicting. To investigate the association between IFNG +874 T>A polymorphism with AR after renal transplantation, relevant studies were selected from PUBMED, EMBASE, Wanfang database and China National Knowledge Infrastructure until March 1st 2013. According the predesigned selection criteria, a total of 525 AR cases and 1,126 non-AR cases from 13 case–control studies were included to identify the strength of association with odds ratio (OR) and 95 % confidence intervals (95 % CI). Overall, a significant correlation between IFNG +874 T>A polymorphism and susceptibility to AR was detected (T allele vs. A allele: OR = 1.19, 95 % CI 1.02–1.38; TT/AT vs. AA: OR = 1.36, 95 % CI 1.07–1.73; TT vs. AA: OR = 1.42, 95 % CI 1.05–1.93; AT vs. AA: OR = 1.30, 95 % CI 1.01–1.68). In addition, ethnicity subgroup analysis revealed that high produce genotype (TT/AT) was associated with an increased risk of AR for Caucasians (TT/AT vs. AA: OR = 1.56, 95 % CI 1.14–2.12; TT vs. AA: OR = 1.64, 95 % CI 1.18–2.26). Furthermore, donor source subgroup analysis observed an increased risk for patients undergoing cadaveric kidney transplantation (TT/AT vs. AA: OR = 1.90, 95 % CI 1.12–3.24; TA vs. AA: OR = 2.16, 95 % CI 1.24–3.74). In conclusion, this meta-analysis suggested that IFNG +874 T>A polymorphism was associated with AR of renal transplant recipients, especially among Caucasians and those receiving cadaveric renal allograft. Additional well-designed studies with large sample size are warranted to validate our conclusion.


Interferon gamma Polymorphism Acute rejection Renal transplantation Meta-analysis 



This project was supported by grants from the National Natural Science Foundation of China (81070597), the Open Key Program of the Jiangsu Province Health Bureau (KF200942), Science and Education Development Program of the Jiangsu Province Health Board (LJ201107) and Six Talent Peaks of the Jiangsu Province Health Bureau (2011-WS-093). My gratitude also goes to Dr. Man-Tang Qiu from the fourth clinical college of Nanjing Medical University for his critical reading of the manuscript and helpful comments.

Conflict of interest

No conflict of interest had been declared by the authors.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Yu-Zheng Ge
    • 1
  • Ran Wu
    • 1
  • Rui-Peng Jia
    • 1
  • Hao Liu
    • 1
  • Peng Yu
    • 1
  • Yan Zhao
    • 1
  • Yu-Ming Feng
    • 1
  1. 1.Department of Urology & Center of Renal TransplantationNanjing Hospital Affiliated to Nanjing Medical UniversityNanjingChina

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