Molecular Biology Reports

, Volume 40, Issue 10, pp 6035–6042 | Cite as

Association between CYP1A1 polymorphisms and esophageal cancer: a meta-analysis

  • Fang-Fang Shen
  • Fu-You Zhou
  • Qi-Si Xue
  • Ying Pan
  • Lu Zheng
  • Hua Zhang
  • Li-Dong Wang
  • Hou-Feng Zheng


Cytochrome P4501A1 (CYP1A1) enzyme is a member of the CYP superfamily of enzymes. CYP1A1 A2455G and T3801C are two most commonly studied polymorphisms loci. Previous studies have reported that CYP1A1 polymorphisms increase esophageal cancer (EC) risk. However, the results remain controversial and ambiguous. To further investigate the association between CYP1A1 polymorphisms (A2455G and T3801C) and EC risk. A meta-analysis was performed to investigate the association between CYP1A1 polymorphisms and EC risk. A total of 13 articles (A2455G and T3801C: 2 papers, A2455G: 8 papers, T3801C: 3 papers) from the PubMed containing information on the CYP1A1 polymorphisms and EC were included in this meta-analysis, with summational sample size of 1,881 EC cases and 3,786 controls. Stratified analysis was performed to evaluate the ethnicity (Caucasians and Asian) and histopathology type (esophageal squamous cell carcinoma and esophageal adenocarcinoma) effect. No obvious publication bias in the two polymorphisms was observed. Our meta-analysis revealed a significant association between the A2455G polymorphism and EC (OR = 1.55 per A allele, 95 % CI 1.29–1.85, P < 0.001). Stratification analysis by ethnicity and histopathology type showed significant association in the population of Asian origin (OR = 1.55, 95 % CI 1.28–1.89, P < 0.001) and in histopathology type of ESCC (OR = 1.40, 95 % CI 1.19–1.65, P < 0.001). We didn’t observe the significant association between CYP1A1 T3801C polymorphism and EC. We observed a difference of allele frequencies between Caucasian and Asian population in the meta-analysis. The allele frequencies in our meta-analysis were consistent with the allele frequencies in 1000 Genome Project. Our meta-analysis demonstrated distinct evidence that CYP1A1 A2455G polymorphism was associated with the risk of EC.


CYP1A1 Esophageal cancer Polymorphism Meta-analysis 



Dr. Hou-Feng Zheng is supported by the Canadian Institutes of Health Research (CIHR). We thank Dr. Wan-Cai Yang from the School of Basal Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China, for carefully reading of this manuscript.

Conflict of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Fang-Fang Shen
    • 1
  • Fu-You Zhou
    • 2
  • Qi-Si Xue
    • 3
  • Ying Pan
    • 1
  • Lu Zheng
    • 4
  • Hua Zhang
    • 1
  • Li-Dong Wang
    • 5
  • Hou-Feng Zheng
    • 6
    • 7
  1. 1.The Key Laboratory for Tumor Translational Medicine, The Third Affiliated HospitalXinxiang Medical UniversityXinxiangChina
  2. 2.Department of Thoracic SurgeryAnyang Tumor HospitalAnyangChina
  3. 3.Intensive Care UnitRoyal Victoria HospitalMontrealCanada
  4. 4.Fuzhou Medical CollegeNanchang UniversityNanchangChina
  5. 5.Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated HospitalZhengzhou UniversityZhengzhouChina
  6. 6.Department of Medicine and Human GeneticsMcGill UniversityMontrealCanada
  7. 7.Department of Epidemiology and BiostatisticsLady Davis Institute, Jewish General HospitalMontrealCanada

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