Molecular Biology Reports

, Volume 40, Issue 3, pp 2733–2740 | Cite as

The application of super paramagnetic iron oxide-labeled mesenchymal stem cells in cell-based therapy

  • Yiying Qi
  • Gang Feng
  • Zhongming Huang
  • Weiqi Yan


Mesenchymal stem cell (MSC)-based therapy has great potential for tissue regeneration. However, being able to monitor the in vivo behavior of implanted MSCs and understand the fate of these cells is necessary for further development of successful therapies and requires an effective, non-invasive and non-toxic technique for cell tracking. Super paramagnetic iron oxide (SPIO) is an idea label and tracer of MSCs. MRI can be used to follow SPIO-labeled MSCs and has been proposed as a gold standard for monitoring the in vivo biodistribution and migration of implanted SPIO-labeled MSCs. This review discusses the biological effects of SPIO labeling on MSCs and the therapeutic applications of local or systemic delivery of these labeled cells.


Mesenchymal stem cells (MSCs) Super paramagnetic iron oxide (SPIO) Label Magnetic resonance imaging (MRI) Target 



The project was supported by the Science Technology Program of Zhejiang Province (2008C13025); the Natural Science Foundation of China (81071259, 81271356) and the Natural Science Grants of Zhejiang Province (Y2090283, LZ12H16002).

Conflict of interest

All authors have no conflicts of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Yiying Qi
    • 1
  • Gang Feng
    • 1
  • Zhongming Huang
    • 1
  • Weiqi Yan
    • 1
  1. 1.Department of Orthopaedic Surgery, The Second Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina

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