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Molecular Biology Reports

, Volume 40, Issue 2, pp 1529–1529 | Cite as

DJ-1 and its emerging role as a biomarker of systemic malignancies besides lung carcinomas

  • Shailendra Kapoor
Article

Keywords

Breast Carcinoma Lung Carcinoma Pancreatic Carcinoma Prostate Carcinoma Esophageal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

To the Editor,

I read with great interest the recent article by Bai et al. [1] in a recent issue of your esteemed journal. The article is highly thought provoking. Interestingly, the past few years have seen the emergence of DJ-1 as a significant biomarker of a number of other systemic malignancies besides lung carcinomas.

For instance, marked variation is seen in serum DJ-1 levels in patients with benign prostatic hypertrophy in comparison to serum DJ-1 levels in patients with prostate carcinomas, with higher levels being seen in the latter [2]. As a result, serum DJ-1 appears to be a biomarker with considerable promise for identifying prostate malignancies. Similarly, DJ-1 is emerging as a promising marker of pancreatic carcinomas [3, 4].

Similarly, higher DJ-1 levels have been noted in nipple secretions from breast carcinoma patients and thus DJ-1 serves as a marker of breast malignancy. In fact, Oda et al. [5] have recently reported that a DJ-1 level greater than 3 nm/mm has a sensitivity of 75 % in predicting breast carcinomas. Similarly, DJ-1 serves as a biomarker of malignancy in laryngeal squamous cell carcinomas. This is confirmed by the fact that the tumor recurrence rate in laryngeal carcinomas that demonstrate up regulated DJ-1 levels is almost twice that in laryngeal carcinomas that exhibit lower DJ-1 levels [6].

DJ-1 is also emerging as a marker of malignancy in other gastrointestinal malignancies besides pancreatic carcinomas. For instance, hepato-cellular carcinomas exhibit augmented DJ-1 levels in comparison to benign liver tissue. Higher DJ-1 levels in fact indicate poor prognosis in hepato-cellular carcinomas [7]. Similarly, DJ-1 promotes tumor proliferation in esophageal carcinomas via the phosphatidylinositol 3-kinase pathway and thereby serves as a marker of poor prognosis in these tumors [8].

The above examples clearly illustrate the significant role of DJ-1 in systemic carcinogenesis and the need for further large scale studies to fully elaborate and understand its carcinogenic effects.

References

  1. 1.
    Bai J, Guo C, Sun W et al (2012) DJ-1 may contribute to metastasis of non-small cell lung cancer. Mol Biol Rep 39:2697–2703PubMedCrossRefGoogle Scholar
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    Lisitskaia KV, Eremina LS, Ivanov AV et al (2011) Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients. Biomed Khim 57:392–401PubMedGoogle Scholar
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    Chen Y, Kang M, Lu W et al (2012) DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. J Cancer Res Clin Oncol 138(9):1463–1474PubMedCrossRefGoogle Scholar
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    Zeng HZ, Qu YQ, Zhang WJ, Xiu B, Deng AM, Liang AB (2011) Proteomic analysis identified DJ-1 as a cisplatin resistant marker in non-small cell lung cancer. Int J Mol Sci 12:3489–3499PubMedCrossRefGoogle Scholar
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    Oda M, Makita M, Iwaya K et al (2012) High levels of DJ-1 protein in nipple fluid of patients with breast cancer. Cancer Sci 103(6):1172–1176PubMedCrossRefGoogle Scholar
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    Zhu XL, Wen WP, Lei WB et al (2010) DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:497–501PubMedGoogle Scholar
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    Liu S, Yang Z, Wei H et al (2010) Increased DJ-1 and its prognostic significance in hepatocellular carcinoma. Hepatogastroenterology 57:1247–1256PubMedGoogle Scholar
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    Yuen HF, Chan YP, Law S et al (2008) DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 17:3593–3602PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.MechanicsvilleUSA

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