Molecular Biology Reports

, Volume 40, Issue 2, pp 1529–1529 | Cite as

DJ-1 and its emerging role as a biomarker of systemic malignancies besides lung carcinomas

  • Shailendra Kapoor


Breast Carcinoma Lung Carcinoma Pancreatic Carcinoma Prostate Carcinoma Esophageal Carcinoma 
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To the Editor,

I read with great interest the recent article by Bai et al. [1] in a recent issue of your esteemed journal. The article is highly thought provoking. Interestingly, the past few years have seen the emergence of DJ-1 as a significant biomarker of a number of other systemic malignancies besides lung carcinomas.

For instance, marked variation is seen in serum DJ-1 levels in patients with benign prostatic hypertrophy in comparison to serum DJ-1 levels in patients with prostate carcinomas, with higher levels being seen in the latter [2]. As a result, serum DJ-1 appears to be a biomarker with considerable promise for identifying prostate malignancies. Similarly, DJ-1 is emerging as a promising marker of pancreatic carcinomas [3, 4].

Similarly, higher DJ-1 levels have been noted in nipple secretions from breast carcinoma patients and thus DJ-1 serves as a marker of breast malignancy. In fact, Oda et al. [5] have recently reported that a DJ-1 level greater than 3 nm/mm has a sensitivity of 75 % in predicting breast carcinomas. Similarly, DJ-1 serves as a biomarker of malignancy in laryngeal squamous cell carcinomas. This is confirmed by the fact that the tumor recurrence rate in laryngeal carcinomas that demonstrate up regulated DJ-1 levels is almost twice that in laryngeal carcinomas that exhibit lower DJ-1 levels [6].

DJ-1 is also emerging as a marker of malignancy in other gastrointestinal malignancies besides pancreatic carcinomas. For instance, hepato-cellular carcinomas exhibit augmented DJ-1 levels in comparison to benign liver tissue. Higher DJ-1 levels in fact indicate poor prognosis in hepato-cellular carcinomas [7]. Similarly, DJ-1 promotes tumor proliferation in esophageal carcinomas via the phosphatidylinositol 3-kinase pathway and thereby serves as a marker of poor prognosis in these tumors [8].

The above examples clearly illustrate the significant role of DJ-1 in systemic carcinogenesis and the need for further large scale studies to fully elaborate and understand its carcinogenic effects.


  1. 1.
    Bai J, Guo C, Sun W et al (2012) DJ-1 may contribute to metastasis of non-small cell lung cancer. Mol Biol Rep 39:2697–2703PubMedCrossRefGoogle Scholar
  2. 2.
    Lisitskaia KV, Eremina LS, Ivanov AV et al (2011) Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients. Biomed Khim 57:392–401PubMedGoogle Scholar
  3. 3.
    Chen Y, Kang M, Lu W et al (2012) DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer. J Cancer Res Clin Oncol 138(9):1463–1474PubMedCrossRefGoogle Scholar
  4. 4.
    Zeng HZ, Qu YQ, Zhang WJ, Xiu B, Deng AM, Liang AB (2011) Proteomic analysis identified DJ-1 as a cisplatin resistant marker in non-small cell lung cancer. Int J Mol Sci 12:3489–3499PubMedCrossRefGoogle Scholar
  5. 5.
    Oda M, Makita M, Iwaya K et al (2012) High levels of DJ-1 protein in nipple fluid of patients with breast cancer. Cancer Sci 103(6):1172–1176PubMedCrossRefGoogle Scholar
  6. 6.
    Zhu XL, Wen WP, Lei WB et al (2010) DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:497–501PubMedGoogle Scholar
  7. 7.
    Liu S, Yang Z, Wei H et al (2010) Increased DJ-1 and its prognostic significance in hepatocellular carcinoma. Hepatogastroenterology 57:1247–1256PubMedGoogle Scholar
  8. 8.
    Yuen HF, Chan YP, Law S et al (2008) DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 17:3593–3602PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.MechanicsvilleUSA

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