Molecular Biology Reports

, Volume 40, Issue 1, pp 535–543 | Cite as

Transforming growth factor-β genetic polymorphisms on development of liver cirrhosis in a meta-analysis

  • Xiao-Dan Wu
  • Kai Zeng
  • Can-Sheng Gong
  • Jinhua Chen
  • Yan-Qing Chen


Transforming growth factor-β (TGF-β) protein has been supposed to be a risk factor for liver cirrhosis; however, the associations between its genes (TGF-β −509C>T and +869T>C) and liver cirrhosis remained unclear. This study was to quantitatively analyze the correlations by using a meta-analysis. Pubmed, Embase, Wanfang databases were retrieved up to November 1st, 2011. Odds ratio (OR) and 95 % confidence interval (95 %CI) were used to demonstrate the strength of association, and P < 0.05 of Z test indicated statistical significance. Combined analyses were performed by using fixed or random-effect model, depending on between-study heterogeneity. Seven studies were for TGF-β −509C>T polymorphism, and eight studies were for +869T>C polymorphism. Combined results indicated that neither TGF-β −509C>T nor +869T>C polymorphisms were associated with risk of liver cirrhosis [OR (95 % CI): 0.79 (0.60–1.04) for CT vs. TT of −509C>T and 0.87 (0.68–1.12) for CT vs. CC of +869T>C], with no between-study heterogeneity. In addition, subgroups analyses still inferred that two polymorphisms were not associated with risk of liver cirrhosis for HBV-infected patients, Asians and for Population-based studies. This meta-analysis indicated that neither TGF-β −509C>T nor +869T>C polymorphisms were associated with risk of liver cirrhosis, regardless of HBV infection or not.


Transforming growth factor Polymorphism Risk Liver cirrhosis Meta-analysis 



Grants covering the research: We gratefully acknowledge the financial support of the Project supported by the Natural Science Foundation of Fujian Province, China (Grant No. 2012Y0012 ) and the Project supported by the Medical Innovation Foundation of Fujin Province, China (Grant No. 2012-CX-2).

Conflict of interest

None for all authors.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Xiao-Dan Wu
    • 1
  • Kai Zeng
    • 2
  • Can-Sheng Gong
    • 1
  • Jinhua Chen
    • 3
  • Yan-Qing Chen
    • 1
  1. 1.Department of AnesthesiologyFujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical UniversityFuzhouChina
  2. 2.Department of AnesthesiologyThe First Affiliated Hospital, Fujian Medical UniversityFuzhouChina
  3. 3.Department of StatisticsFuzhou General Hospital of Nanjing Military RegionFuzhouChina

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