Molecular Biology Reports

, Volume 39, Issue 10, pp 9535–9547 | Cite as

XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case–control studies

  • Liping Dai
  • Fujiao Duan
  • Peng Wang
  • Chunhua Song
  • Kaijuan Wang
  • Jianying Zhang


X-ray repair cross-complementing group 1 gene (XRCC1) has been implicated in risk for lung cancer. However, the results from different studies remain controversial. In this meta-analysis, we have assessed 44 published case–control studies regarding associations of lung cancer risk with three common polymorphisms, codon 194, codon 280 and codon 399, and −77 T > C in the promoter region of XRCC1. The results in total population showed that the risk for lung cancer was increased among the variant homozygote Trp/Trp of codon 194 polymorphism, compared with the wild type Arg/Arg (OR: 1.19; 95 % CI 1.01–1.39), and the variant genotype CC of −77 T > C polymorphism showed a significantly increased risk of developing lung cancer, compared to wild-type genotype TT (OR: 1.91; 95 % CI 1.24–2.94). However, no associations were found between lung cancer risk and codon 280, codon 399. In the subgroup analyses by ethnicity, the OR for the variant homozygote Trp/Trp of codon 194 was 1.21(95 % CI 1.02–1.43) for Asian. When stratified by source of control, we found a protective effect of codon 194 Arg/Trp genotype (OR: 0.87; 95 % CI 0.77–0.98) and risk effect of codon 399 combined Arg/Gln + Gln/Gln variant genotype (OR: 1.09; 95 % CI 1.01–1.18) for lung cancer on the basis of hospital control. Subgroup analyses by histological types of lung cancer indicated that the heterozygote Arg/Trp in codon 194 could decrease and the combined variant genotype Arg/Gln + Gln/Gln in codon 399 could increase the risk of non-small cell lung cancer (OR: 0.69; 95 % CI 0.57–0.85 and OR: 1.14; 95 % CI 1.04–1.24). In conclusion, this meta-analysis has demonstrated that codon 194, codon 399 and −77 T > C polymorphisms of XRCC1 gene might have contributed to individual susceptibility to lung cancer. To further evaluate effect of XRCC1 polymorphisms, gene–gene interaction and gene-environment interaction on lung cancer risk, a single large sample size study with thousands of subjects is required to get conclusive results.


Lung cancer Polymorphism XRCC1 Meta-analysis 



This research was supported by People’s Republic of China (National Natural Science Foundation of China, No. 30872181, 81072360).


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Liping Dai
    • 1
    • 2
    • 3
  • Fujiao Duan
    • 1
    • 2
    • 3
  • Peng Wang
    • 1
    • 2
    • 3
  • Chunhua Song
    • 1
    • 2
    • 3
  • Kaijuan Wang
    • 1
    • 2
    • 3
  • Jianying Zhang
    • 1
    • 2
    • 3
  1. 1.Department of Epidemiology and Biostatistics, College of Public HealthZhengzhou UniversityZhengzhouChina
  2. 2.Key Laboratory of Tumor EpidemiologyZhengzhouChina
  3. 3.Proteomics Research CenterZhengzhou UniversityZhengzhouChina

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