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Molecular Biology Reports

, Volume 39, Issue 9, pp 8771–8775 | Cite as

Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese

  • Bo Xi
  • Dan He
  • Qijuan Wang
  • Jian Xue
  • Man Liu
  • Jun Li
Article

Abstract

The ADIPOQ gene has been implicated in the etiology of hypertension. However, the results have been inconsistent. In this study, a meta-analysis was performed to assess the associations of ADIPOQ polymorphisms with hypertension risk among the Chinese. Published literature from PubMed, CNKI and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Six studies (1,812 cases and 2,631 controls) for rs2241766 polymorphism and four studies (1,449 cases and 2,175 controls) for rs1501299 polymorphism were identified. A marginally significant association was observed for rs2241766 polymorphism under recessive genetic model (GG vs. GT+TT: OR = 1.22, 95 % CI 1.01–1.48) and for rs1501299 polymorphism under heterogeneous co-dominant model (TG vs. GG: OR = 0.86, 95 % CI 0.75–0.99) and dominant model (TT+TG vs. GG: OR = 0.85, 95 % CI 0.74–0.98). In addition, under other genetic models, there was no significant association for rs2241766 polymorphism (GG vs. TT: OR = 1.20, 95 % CI 0.98–1.48; GT vs. TT: OR = 0.97, 95 % CI 0.85–1.10; GG+GT vs. TT: OR = 1.01, 95 % CI 0.90–1.15) and for rs1501299 polymorphism (TT vs. GG: OR = 0.82, 95 % CI 0.62–1.08; TT vs. TG+GG: OR = 0.87, 95 % CI 0.66–1.14). However, the associations above were not robust by sensitivity analysis. The present meta-analysis indicated the limited evidence of the significant associations between ADIPOQ gene polymorphisms and hypertension susceptibility among the Chinese.

Keywords

Hypertension ADIPOQ Polymorphism Meta-analysis 

Notes

Acknowledgments

This study was supported by National “Twelfth Five-Year” Plan for Science & Technology Support Program (2012BAI03B03), Independent Innovation Foundation of Shandong University (2010GN046), and the Foundation for Outstanding Young Scientist in Shandong Province (BS2011YY026).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Department of Maternal and Child Health Care, School of Public HealthShandong UniversityJinanChina

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