Molecular Biology Reports

, Volume 39, Issue 9, pp 8771–8775 | Cite as

Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese

  • Bo Xi
  • Dan He
  • Qijuan Wang
  • Jian Xue
  • Man Liu
  • Jun Li


The ADIPOQ gene has been implicated in the etiology of hypertension. However, the results have been inconsistent. In this study, a meta-analysis was performed to assess the associations of ADIPOQ polymorphisms with hypertension risk among the Chinese. Published literature from PubMed, CNKI and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Six studies (1,812 cases and 2,631 controls) for rs2241766 polymorphism and four studies (1,449 cases and 2,175 controls) for rs1501299 polymorphism were identified. A marginally significant association was observed for rs2241766 polymorphism under recessive genetic model (GG vs. GT+TT: OR = 1.22, 95 % CI 1.01–1.48) and for rs1501299 polymorphism under heterogeneous co-dominant model (TG vs. GG: OR = 0.86, 95 % CI 0.75–0.99) and dominant model (TT+TG vs. GG: OR = 0.85, 95 % CI 0.74–0.98). In addition, under other genetic models, there was no significant association for rs2241766 polymorphism (GG vs. TT: OR = 1.20, 95 % CI 0.98–1.48; GT vs. TT: OR = 0.97, 95 % CI 0.85–1.10; GG+GT vs. TT: OR = 1.01, 95 % CI 0.90–1.15) and for rs1501299 polymorphism (TT vs. GG: OR = 0.82, 95 % CI 0.62–1.08; TT vs. TG+GG: OR = 0.87, 95 % CI 0.66–1.14). However, the associations above were not robust by sensitivity analysis. The present meta-analysis indicated the limited evidence of the significant associations between ADIPOQ gene polymorphisms and hypertension susceptibility among the Chinese.


Hypertension ADIPOQ Polymorphism Meta-analysis 



This study was supported by National “Twelfth Five-Year” Plan for Science & Technology Support Program (2012BAI03B03), Independent Innovation Foundation of Shandong University (2010GN046), and the Foundation for Outstanding Young Scientist in Shandong Province (BS2011YY026).

Conflict of interest



  1. 1.
    Wu Y, Huxley R, Li L et al (2008) Prevalence, awareness, treatment, and control of hypertension in China: data from the China national nutrition and health survey 2002. Circulation 118:2679–2686CrossRefPubMedGoogle Scholar
  2. 2.
    Harrison M, Maresso K, Broeckel U (2008) Genetic determinants of hypertension: an update. Curr Hypertens Rep 10:488–495CrossRefPubMedGoogle Scholar
  3. 3.
    Kurtz TW, Spence MA (1993) Genetics of essential hypertension. Am J Med 94:77–84CrossRefPubMedGoogle Scholar
  4. 4.
    Cnop M, Havel PJ, Utzschneider KM et al (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 4:459–469Google Scholar
  5. 5.
    Yang WS, Chuang LM (2006) Human genetics of adiponectin in the metabolic syndrome. J Mol Med 84:112–121CrossRefPubMedGoogle Scholar
  6. 6.
    Chow WS, Cheung BM, Tso AW et al (2007) Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension 6:1455–1461CrossRefGoogle Scholar
  7. 7.
    Yan WL, Chen SF, Huang JF et al (2006) Common SNPs of APM1 gene are not associated with hypertension or obesity in Chinese population. Biomed Environ Sci 19:179–184PubMedGoogle Scholar
  8. 8.
    Jeng JR (2007) Plasma adiponectin, T94G gene polymorphism and PAI-1 in patients with and without hypertension. Cardiology 107:30–37CrossRefPubMedGoogle Scholar
  9. 9.
    Tang XM, Li JQ, Wu LR et al (2008) Relationship between adiponectin +45 nucleotide T/G polymorphism and essential hypertension. Tianjin Med J 36:762–764Google Scholar
  10. 10.
    Wang ZL, Xia B, Jiang L et al (2008) Association between adiponectin gene polymorphisms and hypertension. J New Med 18:25–29Google Scholar
  11. 11.
    Leu HB, Chung CM, Lin SJ et al (2011) Adiponectin gene polymorphism is selectively associated with the concomitant presence of metabolic syndrome and essential hypertension. PLoS One 6:e19999CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRefPubMedGoogle Scholar
  13. 13.
    Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748PubMedGoogle Scholar
  14. 14.
    Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101CrossRefPubMedGoogle Scholar
  15. 15.
    Egger M, Davey Smith G, Schneider M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Ong KL, Li M, Tso AW et al (2010) Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol 163:251–257CrossRefPubMedGoogle Scholar
  17. 17.
    Zhang ZB, Yu LJ, Yang KJ et al (2011) Association between single nucleotide polymorphisms (SNPs) at the promoter of adiponectin gene and essential hypertension in Chinese Korean and Han of Yanbian region. Hereditas (Beijing) 33:54–59CrossRefGoogle Scholar
  18. 18.
    Jia M, Qiao BM, Zhang Z et al (2008) Study on correlation of genetic polymorphism of adiponectin promoter and adiponectin level with hypertension and its complications. Chin J Lab Diagn 12:222–226Google Scholar
  19. 19.
    Boccia S, De Feo E, Gallì P et al (2010) A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol 25:765–775CrossRefPubMedGoogle Scholar
  20. 20.
    Zhao T, Zhao J (2011) Genetic effects of adiponectin on blood lipids and blood pressure. Clin Endocrinol (Oxf) 74:214–222CrossRefGoogle Scholar
  21. 21.
    Yu Z, Han S, Cao X et al (2011) Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis. Obesity (Silver Spring). doi: 10.1038/oby.2011.148 Google Scholar
  22. 22.
    Li Y, Li X, Shi L et al (2011) Association of Adiponectin SNP+45 and SNP+276 with type 2 diabetes in Han Chinese populations: a meta-analysis of 26 case–control studies. PLoS One 6:e19686CrossRefPubMedPubMedCentralGoogle Scholar

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© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Department of Maternal and Child Health Care, School of Public HealthShandong UniversityJinanChina

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