Molecular Biology Reports

, Volume 39, Issue 9, pp 8723–8732 | Cite as

MTHFR C677T and A1298C polymorphisms and cervical carcinoma susceptibility: meta-analyses based on 4421 individuals

  • Wen-Lei Zhuo
  • Liang Zhang
  • Jun-Jun Ling
  • Yi Zhu
  • Zheng-Tang Chen


MTHFR polymorphisms have been implicated as risk factors for several cancers. Studies have conducted on the associations of MTHFR polymorphisms with cervical carcinoma risk and have generated inconclusive results. The aim of the present study was to increase power demonstrating the possible relations. Meta-analyses examining the association between MTHFR C677T and A1298C polymorphisms and cervical carcinoma risk were performed. Separate analyses on ethnicity and source of controls were also implemented. Eligible studies were identified for the period up to Dec 2011. Eleven case–control studies containing 1859 cases and 2562 controls regarding MTHFR C677T polymorphisms were selected, of which four studies containing 461 cases and 832 controls described A1298C polymorphisms. For the overall data, no associations of MTHFR C677T polymorphisms with cervical carcinoma were observed (TT vs CC: OR = 1.07; 95 %CI = 0.73–1.58; dominant model: OR = 0.89; 95 %CI = 0.66–1.18; recessive model: OR = 1.13; 95 %CI = 0.84–1.52). In the subgroup analysis by ethnicity, MTHFR 677T allele was associated with decreased cervical cancer susceptibility among Caucasians (TT vs CC: OR = 0.65; 95 %CI = 0.45–0.93; dominant model: OR = 0.70; 95 %CI = 0.58–0.86) but not Asians. As for A1298C polymorphism, no marked associations of A1298C genetic variation with cervical cancer risk were observed (CC vs AA: OR = 1.01; 95 %CI = 0.60–1.73; dominant model: OR = 1.17; 95 %CI = 0.91–1.49; recessive model: OR = 0.99; 95 %CI = 0.60–1.63). Collectively, the results of the present study suggest that MTHFR 677T allele might play a preventive role for cervical carcinoma among Caucasians. A1298C polymorphisms might exert little effect on cervical cancerigenesis.


MTHFR Cervical neoplasm Susceptibility Meta-analysis Polymorphism 


Conflict of interest

None declared.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Institute of Cancer, Xinqiao HospitalThird Military Medical UniversityChongqingChina
  2. 2.Department of Environmental Hygiene, College of Preventive MedicineThird Military Medical UniversityChongqingChina
  3. 3.Department of Otolaryngology, Southwest HospitalThird Military Medical UniversityChongqingChina
  4. 4.College of Food Science and Nutritional EngineeringChina Agriculture UniversityBeijingChina

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