Molecular Biology Reports

, Volume 39, Issue 8, pp 8505–8511 | Cite as

The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis

  • Young Ho Lee
  • Sung Jae Choi
  • Jong Dae Ji
  • Gwan Gyu Song


The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to vasculitis. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across nine comparative studies containing 1,922 vasculitis patients and 11,505 normal control subjects. Meta-analysis showed no association between the T allele and vasculitis in all subjects [odds ratio (OR) 1.046, 95 % confidence interval (CI) 0.755–1.1.451, p = 0.786], and analysis after stratification by ethnicity indicated that the T allele was not associated with vasculitis in Europeans (OR 1.104, 95 % CI 0.798–1.528, p = 0.551). However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228–1.630, p = 1.59 × 10−6) and Wegener’s granulomatosis (WG) (OR 1.829, 95 % CI 1.377–2.431, p = 3.09 × 10−5). In addition, meta-analysis showed an association between the T allele and WG in ANCA-positive subjects (OR 2.042, 95 % CI 1.534–2.719, p = 1.02 × 10−6), but not in ANCA-negative WG patients (OR 0.595, 95 % CI 0.199–1.781, p = 0.353). This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.


Protein tyrosine phosphatase nonreceptor 22 Polymorphism Vasculitis Metaanalysis 



This study is supported by a grant from Korea University Medical Center.

Conflict of interest

The authors have no financial and non-financial conflict of interest to declare.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Young Ho Lee
    • 1
  • Sung Jae Choi
    • 1
  • Jong Dae Ji
    • 1
  • Gwan Gyu Song
    • 1
  1. 1.Division of Rheumatology, Department of Internal MedicineKorea University, Anam Hospital, Korea University College of MedicineSeoulKorea

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