Molecular Biology Reports

, Volume 39, Issue 8, pp 8475–8482 | Cite as

Meta-analysis of MCP-1 promoter −2518 A/G polymorphism and SLE susceptibility

  • Ting Liu
  • Jin-Xia Zhai
  • Han-Yong Wang
  • Xing-Hua Wang
  • Li-Wei Zou
  • Wen-jing Fan
  • Dong-Qing Ye


The aim of this meta-analysis was to summarize results on the association of monocyte chemoattractant protein-1(MCP-1) promoter −2518 A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility. We searches all the publications about the association between MCP-1 promoter −2518 A/G polymorphism and SLE from Pubmed, Elsevier Science Direct, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure. The meta-analysis was performed for genotypes AA verse GG, AA+AG verse GG, AA verse AG+GG, and A allele verse G allele in a fixed/random effect model. A total of 14 studies (2,333 cases and 2,391 controls) were included in the meta-analysis. When all groups were pooled, we had not observed significant association between A allele and G allele (OR = 0.94, 95 %CI = 0.79–1.12, P = 0.50). When analysis were restricted to more ethnically homogeneous populations, the similar results were found in European population and Asian population (OR = 1.05, 95 %CI = 0.75–1.46, P = 0.80; OR = 1.00, 95 %CI = 0.86–1.17, P = 0.99). However, we had not detected a significant association between MCP-1 promoter −2518 A/G polymorphism and SLE when examining the genotypes AA verse GG, AA+AG verse GG, AA verse AG+GG. The meta-analysis did not demonstrate the association between MCP-1 promoter −2518 A/G polymorphism and SLE.


Meta-analysis MCP-1 SLE polymorphism 



We are grateful to all the people who give the help for this study. Especially, we appreciated the help from Rui Ding teacher. This work was supported by Grant from the National Natural Science Foundation of China (30830089).


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Ting Liu
    • 1
  • Jin-Xia Zhai
    • 1
    • 2
  • Han-Yong Wang
    • 1
  • Xing-Hua Wang
    • 1
  • Li-Wei Zou
    • 1
  • Wen-jing Fan
    • 1
  • Dong-Qing Ye
    • 2
  1. 1.Department of Occupational and Environmental Health, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina

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