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Molecular Biology Reports

, Volume 39, Issue 7, pp 7473–7478 | Cite as

Interleukin-17 contributes to cardiovascular diseases

  • Hua-Sheng Ding
  • Jun Yang
  • Jian Yang
  • Jia-Wang Ding
  • Ping Chen
  • Ping Zhu
Article

Abstract

Interleukin (IL)-17 (also known as IL-17A), as the signature cytokine of the newly described T helper 17 (Th17) cell population, is the founding member of a new subclass of cytokines that have highly proinflammatory properties. Recently there is accumulating evidence that stipulates the involvement of IL-17 in the pathogenesis of cardiovascular diseases via amplifying the inflammation induced by other cytokines in synergistic interactions. The present review provides a summary of the potential roles of IL-17 in the context derived from both animal models and clinical settings in cardiovascular diseases, and perspectives for IL-17-targeted cytokine therapy.

Keywords

Interleukin-17 T helper 17 cells Inflammatary response Cardiovascular diseases 

Notes

Acknowledgment

This work was supported in part by the National Natural Science Foundation of China (Grant No. 81170133) and the Natural Science Foundation of Hubei Province, China (Grant No. 2011CDB179).

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Hua-Sheng Ding
    • 1
    • 2
  • Jun Yang
    • 1
    • 2
  • Jian Yang
    • 1
    • 2
  • Jia-Wang Ding
    • 1
    • 2
  • Ping Chen
    • 3
  • Ping Zhu
    • 4
  1. 1.Institute of Cardiovascular DiseasesChina Three Gorges UniversityYichang China
  2. 2.Department of Cardiology, The First College of Clinical Medical SciencesChina Three Gorges UniversityYichang China
  3. 3.Department of Emergency, The First College of Clinical Medical SciencesChina Three Gorges UniversityYichang China
  4. 4.Department of Nephrology, The First College of Clinical Medical SciencesChina Three Gorges UniversityYichang China

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