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Molecular Biology Reports

, Volume 39, Issue 4, pp 4351–4358 | Cite as

The LOX-1 3′UTR188CT polymorphism and coronary artery disease in Turkish patients

  • Özlem Kurnaz
  • A. Başak Akadam-Teker
  • Hülya Yilmaz-Aydoğan
  • Atike Tekeli
  • Turgay İsbir
Article

Abstract

In coronary artery disease (CAD), a potentially reversible factor leading to cardiac death is left ventricular hypertrophy (LVH). The 3′untranslated region (3′UTR) 188CT polymorphism of lectin-like oxidized low-density lipoproteins receptor-1 (LOX-1) gene has been associated with an increased risk for CAD. We aim to investigate, in a Turkish population, whether 3′UTR188CT variation could affect the development of LVH in CAD patients. In a population-based case–control study, we compared 83 cases with CAD and 99 healthy controls for this polymorphism. The LOX-1 3′UTR188CT genotypes were determined by PCR–RFLP technique. LOX-1 3′UTR188 TT genotype was associated with significantly increased systolic blood pressure (P = 0.047) and risk of LVH (P = 0.014, OR: 3.541) when compared with the C allele carriers. In addition, the TT genotype was positively associated with decreased levels of HDL-cholesterol in the control subjects (P = 0.031) and increased levels of VLDL-C in the patient group (P = 0.009). The LOX-1 3′UTR188CT gene polymorphism may predispose to the development of LVH in CAD patients, dependent on blood pressure.

Keywords

Oxidized LDL receptor-1 Coronary artery disease Left ventricular hypertrophy Polymorphism 

Abbreviations

LOX-1

Lectin like oxidized receptor

OxLDL

Oxidized LDL

CAD

Coronary artery disease

LVH

Left ventricular hypertrophy

VSMC

Vascular smooth muscle cell

OLR1

Oxidized LDL receptor-1 gene

3′UTR

3′Untranslated region

BΜΙ

Body mass index

TC

Total cholesterol

TG

Triglyceride

HDL-C

HDL-cholesterol

LDL-C

LDL-cholesterol

VLDL-C

VLDL-cholesterol

SBP

Systolic blood pressure

DBP

Diastolic blood pressure

Notes

Acknowledgment

The present work was supported by the Research Fund of Istanbul University. Project No. T–966/06102006.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Özlem Kurnaz
    • 1
  • A. Başak Akadam-Teker
    • 1
  • Hülya Yilmaz-Aydoğan
    • 1
  • Atike Tekeli
    • 2
  • Turgay İsbir
    • 1
  1. 1.Department of Molecular Medicine, The Institute of Experimental MedicineIstanbul UniversityIstanbulTurkey
  2. 2.Department of Cardiovascular SurgeryMarmara University School of MedicineIstanbulTurkey

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