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Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population

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Abstract

The purinergic 1 receptor (P2RY1) has been implicated in development of heart disease and in individual pharmacodynamic response to anticoagulant therapies. However, the association of polymorphisms in the P2RY1 gene with myocardial infarction (MI), and its associated conditions, has yet to be reported in the literature. We evaluated seven known SNPs in P2RY1 for association with MI in a Latvian population. Seven independent parameters that are related to MI [body mass index (BMI), type 2 diabetes (T2D), angina pectoris, hypertension, hyperlipidemia, atrial fibrillation and heart failure] were investigated. No significant association with MI was observed for any of the polymorphisms. Those SNPs for which the P value was close to significance were located in coding or promoter regions. Intriguingly, carriers of the minor allele in the P2RY1 gene locus showed a tendency towards higher onset age for MI, suggesting a possible protective effect of these SNPs against MI or their contribution in progression as opposed to onset. Finally, a linkage disequilibrium (LD) plot was generated for these polymorphisms in the Latvian population. The results of this study suggest that the role of P2RY1 in individuals from Latvian population is likely to be principally involved in platelet aggregation and thromboembolic diseases, and not as a significant contributing factor to the global metabolic syndrome.

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Acknowledgments

This study was supported by grants from the Latvian Council of Science (LZPSP10.0010.10.04) and Latvian Research Program (4VPP-2010-2/2.1). In addition, partial funding support was provided by the European Science Foundation (1DP/1.1.1.2.0/09/APIA/VIAA/150 to V.I., K.M., and R.P.) and the Swedish Research Council (H.B.S.). We acknowledge the Genome Database of Latvian Population, Latvian Biomedical Research and Study Centre for providing data and DNA samples.

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Authors and Affiliations

  1. Latvian Biomedical Research and Study Centre, Ratsupites str. 1, Riga, 1067, Latvia

    Vita Ignatovica, Raitis Peculis, Kaspars Megnis, Iveta Vaivade, Davids Fridmanis & Janis Klovins

  2. Latvian Research Institute of Cardiology, University of Latvia, Sarlotes iela 1a, Riga, LV, 1001, Latvia

    Gustavs Latkovskis & Andrejs Erglis

  3. Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, BOX 593, 751 24, Uppsala, Sweden

    Helgi B. Schioth

  4. Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu iela 13, Riga, LV, 1002, Latvia

    Gustavs Latkovskis & Andrejs Erglis

  5. Faculty of Medicine, University of Latvia, Sarlotes iela 1a, Riga, LV, 1001, Latvia

    Valdis Pirags

  6. Department of Endocrinology, Pauls Stradins Clinical University Hospital, Pilsonu iela 13, Riga, LV, 1002, Latvia

    Valdis Pirags

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  1. Vita Ignatovica
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Correspondence to Vita Ignatovica or Janis Klovins.

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Ignatovica, V., Latkovskis, G., Peculis, R. et al. Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population. Mol Biol Rep 39, 1917–1925 (2012). https://doi.org/10.1007/s11033-011-0938-4

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