Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population
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The purinergic 1 receptor (P2RY1) has been implicated in development of heart disease and in individual pharmacodynamic response to anticoagulant therapies. However, the association of polymorphisms in the P2RY1 gene with myocardial infarction (MI), and its associated conditions, has yet to be reported in the literature. We evaluated seven known SNPs in P2RY1 for association with MI in a Latvian population. Seven independent parameters that are related to MI [body mass index (BMI), type 2 diabetes (T2D), angina pectoris, hypertension, hyperlipidemia, atrial fibrillation and heart failure] were investigated. No significant association with MI was observed for any of the polymorphisms. Those SNPs for which the P value was close to significance were located in coding or promoter regions. Intriguingly, carriers of the minor allele in the P2RY1 gene locus showed a tendency towards higher onset age for MI, suggesting a possible protective effect of these SNPs against MI or their contribution in progression as opposed to onset. Finally, a linkage disequilibrium (LD) plot was generated for these polymorphisms in the Latvian population. The results of this study suggest that the role of P2RY1 in individuals from Latvian population is likely to be principally involved in platelet aggregation and thromboembolic diseases, and not as a significant contributing factor to the global metabolic syndrome.
KeywordsPurinergic receptor Myocardial infarction Genetic association Heart diseases
This study was supported by grants from the Latvian Council of Science (LZPSP10.0010.10.04) and Latvian Research Program (4VPP-2010-2/2.1). In addition, partial funding support was provided by the European Science Foundation (1DP/188.8.131.52.0/09/APIA/VIAA/150 to V.I., K.M., and R.P.) and the Swedish Research Council (H.B.S.). We acknowledge the Genome Database of Latvian Population, Latvian Biomedical Research and Study Centre for providing data and DNA samples.
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