Molecular Biology Reports

, Volume 39, Issue 2, pp 1575–1583 | Cite as

A meta-analysis on the association between three promoter variants of TNF-α and Crohn’s disease

  • Cui Xie
  • Xiao Feng Liu
  • Mao Sheng Yang


Tumor necrosis factor-alpha (TNF-α) has been regarded as a candidate gene for Crohn’s disease (CD) based on its inflammatory function in immune reaction and the clinical effectiveness of anti-TNF-α therapy. However, studies to date have reported inconsistent findings for the association between TNF-α and CD. The PubMed, EMBASE, and Medline databases were systematically reviewed from all English language publications up to April, 2011. A total of twenty-nine studies concerning the association between CD and the TNF-α promoter polymorphisms of −308G/A, −857C/T and −238G/A were identified, among of them only twenty-three studies match the inclusion criteria (including 3,843 cases and 6,260 controls) and were selected for the statistical test. We found that neither the G allele of −308G/A (OR 1.02, 95% CI 0.87–1.19, P = 0.84), C allele of −857C/T (OR 0.97, 95% CI 0.86–1.09, P = 0.57) and G allele of −238G/A (OR 0.91, 95% CI 0.70–1.18, P = 0.48), and nor their GG (OR 1.05, 95% CI 0.88–1.25, P = 0.59), CC (OR 0.98, 95% CI 0.86–1.12, P = 0.76) and GG (OR 0.92, 95% CI 0.70–1.21, P = 0.55) genotypes were associated with CD susceptibility, respectively. Our meta-analysis demonstrates that three promoter polymorphisms of TNF-α above may not confer susceptibility to CD.


TNF-α Crohn’s disease Susceptibility Meta-analysis 



This work was supported by grants from Chongqing Medical University (No.0124418029, No.XBZD200701), Natural Science Foundation Project of CQ CSTC (No.2008BB5074) and The Program for Excellent Talents of University in Chongqing Municipality. The authors have no conflicts of interest to declare. We would like to thank the anonymous reviewers who made comments valuable to the revision of this article.

Conflict of interest



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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Laboratory of Disorder Genes and Department of Pharmacology, College of PharmacyChongqing Medical UniversityChongqingPeople’s Republic of China
  2. 2.Division of PeriodicalsChongqing Medical University Library, Chongqing Medical UniversityChongqingPeople’s Republic of China

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