Molecular Biology Reports

, Volume 39, Issue 2, pp 1371–1376 | Cite as

Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis

  • Ying Ma
  • Bo Zhang
  • Ren-Kuan Tang
  • Yun Liu
  • Guo-Guang Peng


Some studies have shown that IL-18 was associated with aetiology and progression of asthma. However, the association between single-nucleotide polymorphisms −607C/A (rs1946518) and −137G/C (rs187238) located in the IL-18 gene promoter and asthma risk was still controversial and ambiguous. To derive a more precise effect on the association between these polymorphisms and asthma risk, we performed a meta-analysis based on the currently available evidence of the literature. A total of 5 studies with 1411 cases and 1525 controls for −607C/A polymorphism and 5 studies with 1883 cases and 6645 controls for −137G/C polymorphism were identified to perform a meta-analysis, up to October 2010. Summary ORs and corresponding 95% CIs for IL-18 polymorphisms and asthma were estimated using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. We found that individuals carrying AC/CC genotype of −607C/A polymorphism were associated with an increased asthma risk in recessive model (OR = 1.278; 95% CI, 1.073–1.522). However, no significant association was observed between −137G/C polymorphism and asthma risk under different contrast models. There was no evidence of publication bias. The present meta-analysis suggested that IL-18 −607C/A polymorphism in promoter region was associated with asthma risk.


Interleukin-18 Single nucleotide polymorphism Asthma Meta-analysis 



This project supported by Scientific Research Fund of Sichuan Provincial Education Department under Grant Nos: 2006B029 and 10ZA079.

Conflict of interest


Supplementary material

11033_2011_871_MOESM1_ESM.doc (24 kb)
Supplementary material 1 (DOC 23 kb)


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Ying Ma
    • 1
    • 2
  • Bo Zhang
    • 3
  • Ren-Kuan Tang
    • 4
  • Yun Liu
    • 3
  • Guo-Guang Peng
    • 2
  1. 1.Department of NeurologyAffiliated Hospital of North Sichuan Medical CollegeNanchongPeople’s Republic of China
  2. 2.Department of Neurologythe First Affiliated Hospital of Chongqing Medical UniversityChongqingPeople’s Republic of China
  3. 3.Department of Forensic MedicineNorth Sichuan Medical CollegeNanchongPeople’s Republic of China
  4. 4.Department of Forensic Medicine, Faculty of Basic Medical SciencesChongqing Medical UniversityChongqingPeople’s Republic of China

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