Molecular Biology Reports

, Volume 39, Issue 1, pp 461–465 | Cite as

STR markers for detecting heterogeneity in Indian population

  • Shalu Jain
  • Inusha Panigrahi
  • Jayesh Sheth
  • Sarita Agarwal


Short tandem repeats are highly polymorphic sequences of nucleotides, which are abundant in eukaryotic genome. They form approximately 3% of the total human genome and occur on average in every 10, 000 nucleotides. Due to their small dimension, low mutation, and high level of polymorphism, these markers are intensely used as important genetic markers for mapping studies, disease diagnosis, and human identity testing. In the present study allelic distribution of four autosomal short tandem repeat markers (D21S2055, D21S11, D21S1435 and D21S1411) has been analyzed in Indian population. For determination of heterogeneity and their allelic frequency QF-PCR analysis have been done. All the loci were found highly polymorphic. Marker D21S1411 was the most informative (93.6%) and D21S1435 (70.1%) was the least informative marker in Indian population.


STR markers Allelic distribution QF-PCR Heterogeneity 



The authors are thankful to Department of Biotechnology (DBT), New Delhi, India for providing funds to carry out this study and Sanjay Gandhi PGI for providing infrastructure. SJ is a DBT fellow.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Shalu Jain
    • 1
  • Inusha Panigrahi
    • 2
  • Jayesh Sheth
    • 3
  • Sarita Agarwal
    • 1
  1. 1.Department of Medical GeneticsSanjay Gandhi Post Graduate Institute of Medical SciencesLucknowIndia
  2. 2.Department of PaediatricsPGIMERChandigarhIndia
  3. 3.Institute of Human GeneticsAhmedabadIndia

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