Molecular Biology Reports

, Volume 39, Issue 1, pp 199–208 | Cite as

S100A4 mediated cell invasion and metastasis of esophageal squamous cell carcinoma via the regulation of MMP-2 and E-cadherin activity

  • Hong-Yan Zhang
  • Xian-Zhao Zheng
  • Xin-Hua Wang
  • Xiao-Yan Xuan
  • Feng Wang
  • Shan-Shan Li


It is well documented that S100A4 is upregulated in a large amount of invasive tumors and plays a pivotal role in tumor invasion and metastasis. However, the precise role and mechanism S100A4 exerts in the invasion and metastasis of esophageal squamous cell carcinoma (ESCC) have not been fully elucidated to date. Our data demonstrated that S100A4 was overexpressed in human ESCC tissues, especially in ESCC with poor differentiation, deep invasion and lymph node metastasis. Subsequently, the knockdown of S100A4 by RNAi in ESCC cell line (EC-1) could reduce cell invasion, metastasis and proliferation ability in vitro. Most importantly, S100A4 regulated MMP-2 positively and E-cadherin negatively in vivo and in vitro to some extent. Our results suggest that S100A4 is an important factor in the invasion, metastasis and proliferation of ESCC and may control invasion and metastasis at least in part through the regulation of MMP-2 and E-cadherin activity. S100A4 may serve as a biomarker for progression of ESCC and a potential molecular target for biotherapy of ESCC.


S100A4 Invasion Metastasis Esophageal squamous cell carcinoma 



We thank Prof. Cao (the University of Hong Kong) for providing the EC-1 cell line.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Hong-Yan Zhang
    • 1
  • Xian-Zhao Zheng
    • 2
  • Xin-Hua Wang
    • 3
  • Xiao-Yan Xuan
    • 4
  • Feng Wang
    • 1
  • Shan-Shan Li
    • 1
  1. 1.Department of PathologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  2. 2.Department of NeurologyThe People’s Hospital of Jiaozuo CityJiaozuoPeople’s Republic of China
  3. 3.Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  4. 4.Department of Microbiology and ImmunologyCollege of Basic Medicine of Zhengzhou UniversityZhengzhouPeople’s Republic of China

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