Molecular Biology Reports

, Volume 38, Issue 8, pp 4879–4883 | Cite as

Genetic analysis of the 10 ChrX STRs loci in Chinese Han nationality from Guangdong province

  • Qiu-Ling Liu
  • De-Jian Lu
  • Wei-Wei Wu
  • Hong-Lei Hao
  • Ye-Fei Chen
  • Hu Zhao


This study is to explore the polymorphic nature of X-Chromosome short tandem repeats (ChrX STRs) loci, and to determine its application in kinship tests for forensic cases. A new fluorescent multiplex PCR that simultaneously amplifies the 10 ChX STRs loci in the same PCR reaction had been set up. DXS7132, DXS981, DXS6801, DXS6809, DXS6789, DXS7424, DXS101, DXS7133, GATA165B12 and GATA31E08 were analyzed in a sample of 511 (399 males and 112 females) unrelated individuals from Guangdong Han nationality in China. One hundred and one alleles were observed in all the loci. Here, we investigated the allele frequencies and mutation rates of the ten loci, and then made the comparison of allele frequencies distribution among different populations. The results show the ten loci in the multiplex systems may provide high polymorphism information for kinship testing and relationship investigations, and it is necessary to gain allele frequency and mutation rate of different population for forensic application.


ChrX STRs Fluorescent multiplex PCR Polymorphism 



This work was supported by the Guangdong province innovation experiment program for university students, China(1055810103).

Supplementary material

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Qiu-Ling Liu
    • 1
  • De-Jian Lu
    • 1
  • Wei-Wei Wu
    • 2
  • Hong-Lei Hao
    • 2
  • Ye-Fei Chen
    • 1
  • Hu Zhao
    • 1
  1. 1.Faculty of Forensic Medicine, Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of Criminal InvestigationZhejiang Provincial Public Security BureauHangzhouChina

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