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MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study

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Abstract

In the present study we investigated the association between three polymorphisms of the MUTYH (Tyr165Cys, rs34612342), the OGG1 (Ser326Cys, rs1052133) and the XPD (Lys751Gln, rs13181) genes with head and neck cancer risk. Genotypes were determined in DNA from peripheral blood lymphocytes of 265 patients with head and neck squamous cell carcinoma (HNSCC) as well as 280 cancer-free controls by PCR-restriction fragment lenght polymorphisms. We found an association between HNSCC and the Ser326Cys (OR 1.69; 95% CI 1.19–2.45) as well as Cys326Cys (OR 4.56; 95% CI 2.07–10.05) variants of the OGG1 gene. The gene–gene interaction between MUTYH and OGG1 as well as OGG1 and XPD polymorphic variants may contribute to higher prevalence of HNSCC. We also found an association between Ser326Cys and Cys326Cys variants of OGG1 gene and smoking status in HNSCC patients (OR 1.97; 95% CI 1.25–3.11), (OR 3.54; 95% CI 1.39–9.04), respectively. Moreover, we also observed a protective association between Tyr165Cys variant of the MUTYH gene and non-smoking status in HNSCC (OR 0.34; 95% CI 0.17–0.66). We also found a link between gene–gene interaction (MUTYH and OGG1 or OGG1 and XPD) and smoking (ORs 2.17–4.20 and 2.18–5.23) or non-smoking status (ORs 0.11 and 7.61) in HNSCC patients, respectively. In conclusion our data showed that the Ser326Cys polymorphism of the OGG1 gene may modify the risk of HNSCC associated with smoking. Finally we suggested that this polymorphism might be used as predictive factor for head and neck cancer in Polish population.

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Acknowledgement

This work was supported by Grant N301 099 32/3581 from Polish Ministry of Science and Higher Education.

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The authors declare that there are no conflicts of interests.

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Authors and Affiliations

  1. Department of Molecular Genetics, University of Lodz, 12/16, 90-237, Lodz, Poland

    Tomasz Sliwinski, Pawel Rusin & Ireneusz Majsterek

  2. Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 1, Hallera Sq, 90-647, Lodz, Poland

    Karolina Przybylowska, Lukasz Markiewicz & Ireneusz Majsterek

  3. Department of Otolaryngology, Medical University of Lodz, 90-153, Lodz, Poland

    Wioletta Pietruszewska

  4. Department of Otolaryngology and Oncology, Medical University of Lodz, 90-549, Lodz, Poland

    Hanna Zelinska-Blizniewska & Jurek Olszewski

  5. Department of Head and Neck Cancer, Medical University of Lodz, 93-509, Lodz, Poland

    Alina Morawiec-Sztandera

  6. Department of Pediatrics, Medical University of Lodz, 36/50 Sporna St, 91-738, Lodz, Poland

    Wojciech Mlynarski

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  1. Tomasz Sliwinski
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Sliwinski, T., Przybylowska, K., Markiewicz, L. et al. MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study. Mol Biol Rep 38, 1251–1261 (2011). https://doi.org/10.1007/s11033-010-0224-x

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