DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia
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DNA methylation is involved in genomic imprinting, tissue and stage specific gene regulation, X chromosome inactivation and especially necessary in normal mammalian development . Methylation of DNA at cytosine base occurs at most CpG islands in the mammalian genome, with exception of CpG islands of gene promoters which are usually unmethylated. Methylation of promoter CpG islands inhibits the activity of the gene by inhibiting the association of some DNA-binding factors with methylated DNA sequences or by silencing transcription via methyl-CpG binding proteins with co-repressors and chromatin modifiers .
Cancer is known as a genetic disease, in which epigenetic alterations play important roles. Cancer cells show global genomic hypomethylation, but the CpG islands of the promoters, especially the promoters of the tumour suppressor genes are hypermethylated . Aberrant methylation of CpG islands is a major epigenetic mechanism of gene expression in human cancers....
KeywordsAcute Lymphoblastic Leukemia Proliferate Cell Nuclear Antigen Endometrial Carcinoma AdoMet Blast Count
We acknowledge to Timur Tuncalı, Ongun Onaran and Uygar Tazebay for their technical support and to Kenan Köse for performing statistical analysis. This study was granted by The Scientific and Technological Research Council of Turkey (TUBİTAK).
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