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Molecular Biology Reports

, Volume 37, Issue 1, pp 461–466 | Cite as

Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs

  • Luca Fontanesi
  • Emilio Scotti
  • Luca Buttazzoni
  • Stefania Dall’Olio
  • Alessandro Bagnato
  • Domenico Pietro Lo Fiego
  • Roberta Davoli
  • Vincenzo Russo
Article

Abstract

We recently showed that a polymorphism in the fat mass and obesity associated (FTO) gene (AM931150: g.276T > G) is associated with fat deposition traits in pigs. To confirm this result, we genotyped this polymorphism in an Italian Duroc population made up by 313 performance tested pigs with known estimated breeding values (EBVs) for average daily gain, back fat thickness (BFT), feed:gain ratio, lean cuts (LC), and visible intermuscular fat (VIF, a measure of intermuscular fat in the hams). In addition, we genotyped 148 commercial heavy pigs for which several fat deposition traits and lean meat percentage were measured. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits (VIF, BFT and LC) in the Italian Duroc pigs (P < 0.01) and in the commercial pigs (intramuscular fat content of different muscles, P < 0.05 or P < 0.10; lean meat content, P < 0.05; BFT, P < 0.05; intermuscular fat content in the hams, P < 0.05).

Keywords

Animal model Association study FTO Fat deposition Obesity Pigs 

Notes

Acknowledgments

We thank Dr. M. Yerle (INRA) for providing the INRA-Minnesota 7000 rads RH panel and ANAS for providing samples and data. This work was supported by University of Bologna (FAGenomicH project) and MiPAAF (Selmol project) funds.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Luca Fontanesi
    • 1
  • Emilio Scotti
    • 1
  • Luca Buttazzoni
    • 2
  • Stefania Dall’Olio
    • 1
  • Alessandro Bagnato
    • 3
  • Domenico Pietro Lo Fiego
    • 4
  • Roberta Davoli
    • 1
  • Vincenzo Russo
    • 1
  1. 1.DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of AgricultureUniversity of BolognaReggio EmiliaItaly
  2. 2.Associazione Nazionale Allevatori Suini (ANAS)RomeItaly
  3. 3.Department of Veterinary Sciences and Technologies for Food Safety, Faculty of Veterinary MedicineUniversita` degli Studi di MilanoMilanItaly
  4. 4.Department of Agricultural and Food Sciences, Faculty of AgricultureUniversity of Modena and Reggio EmiliaReggio EmiliaItaly

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