Molecular Biology Reports

, Volume 37, Issue 1, pp 47–50 | Cite as

Association of LT-α Ala252Gly gene polymorphism and the genetic predisposition of coronary heart disease in Chinese

  • Hanxiang Gao
  • Zheng Zhang
  • Jin Zhang
  • Nan Zhao
  • Qiang Li
  • Ming Bai


About the role of lymphotoxin α (LTA) gene in coronary heart disease, controversy reports exists. So the purpose of the present study was to investigate the possible involvement of LTA in the pathogenesis of atherosclerosis and MI in Chinese. In a cross-sectional design, we studied 57 coronary heart disease patients with family history of coronary heart disease and in another control group of 62 healthy subjects (mean age 56 years; range 32–78 years). Body mass index, the levels of blood pressure, the plasma levels of lipoproteins, cholesterol, and triglycerides were measured, smoking data were self-reported, and LTA genotypes were determined. LTA Ala252Gly gene polymorphism had two alleles (LTA1 and LTA2) and three kinds of genotype: homozygote LTA G/G, LTA A/A, and heterozygote LTA A/G. No population significant differences were detected in LTA genotypes and allele frequencies between coronary heart disease patients or healthy controls (χ 2 = 1.479, P = 0.477 > 0.05). LTA Ala252Gly gene polymorphism was not associated with the genetic predisposition of coronary heart disease.


Coronary heart disease Gene polymorphism Lymphotoxin α 



The chief acknowledgment for the study is to the patients and their relatives who collaborated, to their general practitioners, and to the medical and nursing staff from the first hospital of Lanzhou University in China. I thank Professor Zheng Zhang (Director of the cardiac rehabilitation department and cardiovascular care unit) and associate Professor Jin Zhang (for checking the article), and the Research Center of Molecular Biology of Gansu Province, respectively. Study was supported by medical scientific research foundation of Lanzhou university.


  1. 1.
    Naoum JJ, Chai H, Lin PH et al (2006) Lymphotoxin-a and cardiovascular disease: clinical association and pathogenic mechanisms. Med Sci Monit 12(7):RA121–RA124PubMedGoogle Scholar
  2. 2.
    Kuiper J, van Puijvelde GH, van Wanrooij EJ et al (2007) Immunomodulation of the inflammatory response in atherosclerosis. Curr Opin Lipidol 18(5):521–526CrossRefPubMedGoogle Scholar
  3. 3.
    Okopień B, Basiak M, Madej A et al (2006) Markers of inflammatory process in stable and unstable coronary artery disease. Pol Merkur Lekarski 21(121):69–72PubMedGoogle Scholar
  4. 4.
    Schneider K, Potter KG, Ware CF (2004) Lymphotoxin and LIGHT signaling pathways and target genes. Immunol Rev 202:49–66CrossRefPubMedGoogle Scholar
  5. 5.
    Ware CF (2005) Network communications: lymphotoxins, LIGHT, and TNF. Annu Rev Immunol 23:787–819CrossRefPubMedGoogle Scholar
  6. 6.
    Spahn TW, Eugster HP, Fontana A et al (2005) Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway. Infect Immun 73:7077–7088CrossRefPubMedGoogle Scholar
  7. 7.
    Madamanchi NR, Tchivilev I, Runge M (2006) Genetic markers of oxidative stress and coronary atherosclerosis. Curr Atheroscler Rep 8(3):177–183CrossRefPubMedGoogle Scholar
  8. 8.
    Anderson JL, Adams CD, Antman EM et al (2007) ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American college of cardiology/American heart association task force on practice guidelines (Writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction): developed in collaboration with the American college of emergency physicians, the society for cardiovascular angiography and interventions, and the society of thoracic surgeons: endorsed by the American association of cardiovascular and pulmonary rehabilitation and the society for academic emergency medicine. Circulation 116(7):e148–e304CrossRefPubMedGoogle Scholar
  9. 9.
    Antman EM, Anbe DT, Armstrong PW et al (2004) ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American college of cardiology/American heart association task force on practice guidelines (Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). Circulation 110(9):e82–e292PubMedGoogle Scholar
  10. 10.
    Gibbons RJ, Abrams J, Chatterjee K et al (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article: a report of the American college of cardiology/American heart association task force on practice guidelines (Committee on the management of patients with chronic stable angina). Circulation 107(1):149–158CrossRefPubMedGoogle Scholar
  11. 11.
    Grupo de Trabajo para el Tratamiento de la Hipertensión Arterial de la Sociedad Europea; Sociedad Europea de Cardiología, Mancia G et al (2007) ESH/ESC 2007 guidelines for the management of arterial hypertension. Rev Esp Cardiol 60(9):968.e1–e94Google Scholar
  12. 12.
    Ozaki K, Ohnishi Y, Iida A et al (2002) Functional SNPs in the lymphotoxin alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 32(4):650–654CrossRefPubMedGoogle Scholar
  13. 13.
    Kimura A, Takahashi M, Choi BY et al (2007) Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations. Tissue Antigens 69(3):265–269CrossRefPubMedGoogle Scholar
  14. 14.
    Sedlacek K, Neureuther K, Mueller JC et al (2007) Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. J Mol Med 85(9):997–1004CrossRefPubMedGoogle Scholar
  15. 15.
    Clarke R, Xu P, Bennett D et al (2006) Lymphotoxin-a gene and risk of myocardial infarction in 6, 928 cases and 2, 712 controls in the ISIS case–control study. PLoS Genet 2(7):0990–0996CrossRefGoogle Scholar
  16. 16.
    Yamada A, Ichihara S, Murase Y et al (2004) Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese. J Mol Med 82:477–483PubMedGoogle Scholar
  17. 17.
    Asselbergs FW, Pai JK, Rexrode KM et al (2007) Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. Clin Sci (Lond) 112(5):291–298CrossRefGoogle Scholar
  18. 18.
    Koch W, Hoppmann P, Michou E et al (2007) Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans. Human Mol Genet 16:1821–1827CrossRefGoogle Scholar
  19. 19.
    Jang Y, Koh SJ, Kim OY et al (2007) Effect of the 252A > G polymorphism of the lymphotoxin-α gene on inflammatory markers of response to cigarette smoking in Korean healthy men. Clin Chim Acta 377(1–2):221–227CrossRefPubMedGoogle Scholar
  20. 20.
    Zondervan K, Cardon LR et al (2004) The complex interplay among factors that influence allelic association. Nat Rev Genet 5:89–100CrossRefPubMedGoogle Scholar
  21. 21.
    Marchini J, Cardon LR, Phillips MS et al (2004) The effects of human population structure on large genetic association studies. Nat Genet 36:512–517CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Hanxiang Gao
    • 1
  • Zheng Zhang
    • 1
    • 2
  • Jin Zhang
    • 1
  • Nan Zhao
    • 1
  • Qiang Li
    • 1
  • Ming Bai
    • 1
  1. 1.Clinical Medical CollegeThe First Hospital of Lanzhou UniversityLanzhouChina
  2. 2.Department of CardiovascularThe First Hospital of Lanzhou UniversityLanzhouChina

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