Association of LT-α Ala252Gly gene polymorphism and the genetic predisposition of coronary heart disease in Chinese
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About the role of lymphotoxin α (LTA) gene in coronary heart disease, controversy reports exists. So the purpose of the present study was to investigate the possible involvement of LTA in the pathogenesis of atherosclerosis and MI in Chinese. In a cross-sectional design, we studied 57 coronary heart disease patients with family history of coronary heart disease and in another control group of 62 healthy subjects (mean age 56 years; range 32–78 years). Body mass index, the levels of blood pressure, the plasma levels of lipoproteins, cholesterol, and triglycerides were measured, smoking data were self-reported, and LTA genotypes were determined. LTA Ala252Gly gene polymorphism had two alleles (LTA1 and LTA2) and three kinds of genotype: homozygote LTA G/G, LTA A/A, and heterozygote LTA A/G. No population significant differences were detected in LTA genotypes and allele frequencies between coronary heart disease patients or healthy controls (χ 2 = 1.479, P = 0.477 > 0.05). LTA Ala252Gly gene polymorphism was not associated with the genetic predisposition of coronary heart disease.
KeywordsCoronary heart disease Gene polymorphism Lymphotoxin α
The chief acknowledgment for the study is to the patients and their relatives who collaborated, to their general practitioners, and to the medical and nursing staff from the first hospital of Lanzhou University in China. I thank Professor Zheng Zhang (Director of the cardiac rehabilitation department and cardiovascular care unit) and associate Professor Jin Zhang (for checking the article), and the Research Center of Molecular Biology of Gansu Province, respectively. Study was supported by medical scientific research foundation of Lanzhou university.
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