Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease

  • Qi Qian
  • Zhong Chen
  • Genshan Ma
  • Yibo Jiang
  • Yi Feng
  • Chengxing Shen
  • Yuyu Yao
  • Jiandong Ding
  • Qiming Dai
  • Yongjun Li


Background Inflammation plays an important role in coronary artery disease (CAD). Complement Factor H (CFH) gene has been analyzed in relation to CAD in several studies with conflicting results. The aim of the present study was to investigate the association between the CFH Y402H polymorphism and CAD in Chinese. Methods and results About 336 patients were enrolled, included 166 patients with CAD and 170 controls. The SNP at CFH Y402H was genotyped by ligase detection reaction and plasma levels of CFH were assayed by enzyme-linked immunosorbent assay. Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of C allele and C allele carriers between early-onset CAD and controls. After adjustment of clinical parameters, significant association was identified for CFH Y402H polymorphism, with C allele carriers having a higher risk of early-onset CAD than carriers of TT genotype (odds ratio [OR] 4.66, 95% CI: 1.23–17.62, = 0.02). There was no difference of plasma CFH levels between CAD group and controls. Conclusions CFH Y402H polymorphism is associated with early-onset CAD in Chinese.


Single nucleotide polymorphism Coronary artery disease Early-onset Gene polymorphism Complement factor H 



Coronary artery disease


Complement factor H




Single nucleotide polymorphism


Myocardial infarction


Age-related macular degeneration



This study was supported by Jiangsu Social Development Grant for 2007 (BS2007047).


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Qi Qian
    • 1
  • Zhong Chen
    • 1
  • Genshan Ma
    • 1
    • 2
  • Yibo Jiang
    • 1
  • Yi Feng
    • 1
  • Chengxing Shen
    • 1
  • Yuyu Yao
    • 1
  • Jiandong Ding
    • 1
  • Qiming Dai
    • 1
  • Yongjun Li
    • 1
  1. 1.Clinical Medical College of Southeast UniversityNanjingPeople’s Republic of China
  2. 2.Department of CardiologyThe Affiliated ZhongDa Hospital of Southeast UniversityNanjingPeople’s Republic of China

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