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Molecular Biology Reports

, 36:159 | Cite as

Effect of Terminalia arjuna on antioxidant defense system in cancer

  • Nibha Verma
  • Manjula Vinayak
Article

Abstract

Constant production of reactive oxygen species (ROS) during aerobic metabolism is balanced by antioxidant defense system of an organism. Although low level of ROS is important for various physiological functions, its accumulation has been implicated in the pathogenesis of age-related diseases such as cancer and coronary heart disease and neurodegenerative disorders such as Alzheimer’s disease. It is generally assumed that frequent consumption of phytochemicals derived from vegetables, fruits, tea and herbs may contribute to shift the balance towards an adequate antioxidant status. The present study is aimed to investigate the effect of aqueous extract of medicinal plant Terminalia arjuna on antioxidant defense system in lymphoma bearing AKR mice. Antioxidant action of T. arjuna is monitored by the activities of catalase, superoxide dismutase and glutathione S transferase which constitute major antioxidant defense system by scavenging ROS. These enzyme activities are low in lymphoma bearing mice indicating impaired antioxidant defense system. Oral administration of different doses of aqueous extract of T. arjuna causes significant elevation in the activities of catalase, superoxide dismutase and glutathione S transferase. T. arjuna is found to down regulate anaerobic metabolism by inhibiting the activity of lactate dehydrogenase in lymphoma bearing mice, which was elevated in untreated cancerous mice. The results indicate the antioxidant action of aqueous extract of T. arjuna, which may play a role in the anti carcinogenic activity by reducing the oxidative stress along with inhibition of anaerobic metabolism.

Keywords

Terminalia arjuna Catalase Superoxide dismutase Glutathione S transferase Antioxidant action Lactate dehydrogenase Reactive oxygen species 

Notes

Acknowledgements

Nibha Verma thanks Indian Council of Medical Research, New Delhi, India for providing Senior Research Fellowship. The work is supported by the grants received from University Grants Commission, India under CAS programme.

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in ZoologyBanaras Hindu UniversityVaranasiIndia

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