An association between angiotensin II type 2 receptor gene A/C3123 polymorphism and glycemic control marker in a general Japanese population

  • Kazuhiko Kotani
  • Shinji Fujiwara
  • Kokoro Tsuzaki
  • Yoshiko Sano
  • Yukiyo Matsuoka
  • Taku Hamada
  • Naoki Sakane


Objective Angiotensin II (Ang II), through the Ang II type 2 receptor (AT2R), may play some roles in the pathogenesis of glucose metabolism and diabetes mellitus (DM). The Adenine/Cytosine 3123 (A/C3123) polymorphism in the AT2R gene has reportedly been associated with metabolic conditions such as blood pressure and body mass index (BMI). The present cross-sectional study was aimed at investigating the association between the AT2R gene A/C3123 polymorphism and glycemic control parameters. Methods Among 286 community-dwelling Japanese subjects (men: women = 126:160; mean age, 65.1 years), AT2R A/C3123 polymorphism, which was detected by polymerase chain reaction methods, and metabolic parameters such as blood pressure, BMI, lipoprotein/lipid, insulin, and glycemic control parameters (fasting plasma glucose and HbA1c) were examined. Results In the whole study population, the proportion of C-allele was 67.0% and A-allele was 33.0%. The A-allele carriers had significantly lower HbA1c levels than the C/C-genotyped subjects in the group of women (5.5 ± 0.6 vs. 5.8 ± 1.5%, P = 0.042). The effect on HbA1c persisted to be significant with adjustments to age and BMI. In men, the associations between the polymorphism and glycemic control parameters were non-significantly noted. There were no differences between genotype-based groups in the other metabolic parameters in both sexes. Conclusion These results suggest that the AT2R A/C3123 polymorphism could be a polymorphic marker related to glycemic control, as presented in HbA1c, among general Japanese women.


Renin-angiotensin system HbA1c Polymorphic marker 


Ang II

Angiotensin II


Diabetes mellitus




Body mass index


Renin-angiotensin system


Angiotensin-converting enzyme


Plasma glucose


Fasting plasma glucose


Postprandial hyperglycemia



This study was supported in part by a Grant-in-Aid from the Foundation for the Development of the Community, Japan and by the Japanese Ministry of Education and Science Grant-in-Aid for Science Research (C), Japan.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Kazuhiko Kotani
    • 1
    • 2
  • Shinji Fujiwara
    • 3
  • Kokoro Tsuzaki
    • 1
  • Yoshiko Sano
    • 1
  • Yukiyo Matsuoka
    • 1
  • Taku Hamada
    • 1
  • Naoki Sakane
    • 1
  1. 1.Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic DiseaseNational Hospital Organization Kyoto Medical CenterKyotoJapan
  2. 2.Division of Health Administration and Promotion, Faculty of MedicineTottori UniversityYonagoJapan
  3. 3.Division of Community and Family MedicineJichi Medical UniversityTochigiJapan

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