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An association between angiotensin II type 2 receptor gene A/C3123 polymorphism and glycemic control marker in a general Japanese population

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Abstract

Objective Angiotensin II (Ang II), through the Ang II type 2 receptor (AT2R), may play some roles in the pathogenesis of glucose metabolism and diabetes mellitus (DM). The Adenine/Cytosine 3123 (A/C3123) polymorphism in the AT2R gene has reportedly been associated with metabolic conditions such as blood pressure and body mass index (BMI). The present cross-sectional study was aimed at investigating the association between the AT2R gene A/C3123 polymorphism and glycemic control parameters. Methods Among 286 community-dwelling Japanese subjects (men: women = 126:160; mean age, 65.1 years), AT2R A/C3123 polymorphism, which was detected by polymerase chain reaction methods, and metabolic parameters such as blood pressure, BMI, lipoprotein/lipid, insulin, and glycemic control parameters (fasting plasma glucose and HbA1c) were examined. Results In the whole study population, the proportion of C-allele was 67.0% and A-allele was 33.0%. The A-allele carriers had significantly lower HbA1c levels than the C/C-genotyped subjects in the group of women (5.5 ± 0.6 vs. 5.8 ± 1.5%, P = 0.042). The effect on HbA1c persisted to be significant with adjustments to age and BMI. In men, the associations between the polymorphism and glycemic control parameters were non-significantly noted. There were no differences between genotype-based groups in the other metabolic parameters in both sexes. Conclusion These results suggest that the AT2R A/C3123 polymorphism could be a polymorphic marker related to glycemic control, as presented in HbA1c, among general Japanese women.

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Abbreviations

Ang II:

Angiotensin II

DM:

Diabetes mellitus

A/C:

Adenine/Cytosine

BMI:

Body mass index

RAS:

Renin-angiotensin system

ACE:

Angiotensin-converting enzyme

PG:

Plasma glucose

FPG:

Fasting plasma glucose

PPHG:

Postprandial hyperglycemia

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Acknowledgements

This study was supported in part by a Grant-in-Aid from the Foundation for the Development of the Community, Japan and by the Japanese Ministry of Education and Science Grant-in-Aid for Science Research (C), Japan.

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Authors and Affiliations

  1. Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

    Kazuhiko Kotani, Kokoro Tsuzaki, Yoshiko Sano, Yukiyo Matsuoka, Taku Hamada & Naoki Sakane

  2. Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan

    Kazuhiko Kotani

  3. Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan

    Shinji Fujiwara

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  1. Kazuhiko Kotani
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  2. Shinji Fujiwara
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  3. Kokoro Tsuzaki
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  4. Yoshiko Sano
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  7. Naoki Sakane
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Correspondence to Kazuhiko Kotani.

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Kotani, K., Fujiwara, S., Tsuzaki, K. et al. An association between angiotensin II type 2 receptor gene A/C3123 polymorphism and glycemic control marker in a general Japanese population. Mol Biol Rep 36, 917–920 (2009). https://doi.org/10.1007/s11033-008-9263-y

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  • DOI: https://doi.org/10.1007/s11033-008-9263-y

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