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A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease

  • Zhong Chen
  • Qi Qian
  • Genshan Ma
  • Jiahong Wang
  • Xiaoli Zhang
  • Yi Feng
  • Chengxing Shen
  • Yuyu Yao
Article

Abstract

Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis 50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio [OR] 2.207, 95% CI: 1.069–4.394, = 0.028; OR 3.051, 95% CI: 1.086–8.567, = 0.004; OR 2.964, 95% CI: 1.063–8.265, = 0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary artery disease (both > 0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the identification of patients at increased risk for early-onset coronary artery disease.

Keywords

Coronary artery disease Early-onset Single nucleotide polymorphisms Genetic Gene 

Abbreviations

CAD

Coronary artery disease

CI

Confidence interval

MI

Myocardial infarction

OR

Odds ratio

SNP

Single nucleotide polymorphism

Notes

Acknowledgment

This study was supported by Nanjing Scientific Development Grant for 2006 (2006ZD016).

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Zhong Chen
    • 1
  • Qi Qian
    • 1
  • Genshan Ma
    • 1
  • Jiahong Wang
    • 1
  • Xiaoli Zhang
    • 1
  • Yi Feng
    • 1
  • Chengxing Shen
    • 1
  • Yuyu Yao
    • 1
  1. 1.Department of CardiologyThe Affiliated ZhongDa Hospital of Southeast UniversityNanjingPeople’s Republic of China

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