Synthesis of tetracyclic pyrido-fused dibenzodiazepines via a catalyst-free cascade reaction


An efficient, eco-friendly protocol has been described for the chemoselective synthesis of tetracyclic pyrido-fused dibenzodiazepines derivatives via catalyst-free, three-component reaction of dimedone, 1,2-diamines, 3-formylchromones, and malononitrile. The significant advantages of this cascade approach are to create two new rings and four new σ bonds containing three C–N and one C–C bond, as well as the breakdown of a C–O bond.

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The author would like to thank Esmat Sodagar, a postdoctoral fellow at the University of Southern California.

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Correspondence to Abdolali Alizadeh.

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Alizadeh, A., Bagherinejad, A. Synthesis of tetracyclic pyrido-fused dibenzodiazepines via a catalyst-free cascade reaction. Mol Divers (2020).

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  • Enaminone
  • Dibenzo[b,f]pyrido[1,2-d][1,4]diazepine
  • Knoevenagel condensation
  • Chemoselective
  • Three-component cascade reaction
  • Catalyst free
  • Tetracyclic ring
  • Seven-membered ring