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Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction

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Abstract

Electro-synthesis through a one-pot three-component condensation of corresponding aldehydes, Meldrum’s acid, and 2-(nitromethylene)imidazolidine resulted in a series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing an electronegative pharmacophore (=CNO2). The process was carried out in propanol medium with sodium bromide presented as electrolyte, inside an undivided cell with good to excellent yields. As a powerful entry into fused polycyclic structures related to bioactive heterocycles, this green protocol shows great potential.

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Authors and Affiliations

  1. Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran

    Mohammad Reza Asghariganjeh

  2. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

    Mohammad Reza Asghariganjeh, Elham Tahanpesar & Ayeh Rayatzadeh

  3. Chemistry and Chemical Engineering Research Center of Iran (CCERCI), 14335-186, Tehran, Iran

    Ali Asghar Mohammadi

  4. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    Somayeh Makarem

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  1. Mohammad Reza Asghariganjeh
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Asghariganjeh, M.R., Mohammadi, A.A., Tahanpesar, E. et al. Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction. Mol Divers 25, 509–516 (2021). https://doi.org/10.1007/s11030-019-10029-6

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