Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction

Abstract

Electro-synthesis through a one-pot three-component condensation of corresponding aldehydes, Meldrum’s acid, and 2-(nitromethylene)imidazolidine resulted in a series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing an electronegative pharmacophore (=CNO2). The process was carried out in propanol medium with sodium bromide presented as electrolyte, inside an undivided cell with good to excellent yields. As a powerful entry into fused polycyclic structures related to bioactive heterocycles, this green protocol shows great potential.

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Asghariganjeh, M.R., Mohammadi, A.A., Tahanpesar, E. et al. Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction. Mol Divers 25, 509–516 (2021). https://doi.org/10.1007/s11030-019-10029-6

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Keywords

  • Electro-organic synthesis
  • Imidazo[1,2-a]pyridine
  • Multicomponent reaction
  • 2-(Nitromethylene)imidazolidine
  • Meldrum’s acid