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Coumarins: antifungal effectiveness and future therapeutic scope

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Abstract

The antifungals that are in current clinical practice have a high occurrence of a side effect and multidrug resistance (MDR). Researchers across the globe are trying to develop a suitable antifungal that has minimum side effect as well as no MDR issues. Due to serious undesired effects connected with individual antifungals, it is now necessary to introduce novel and effective drugs having numerous potentials to regulate complex therapeutic targets of several fungal infections simultaneously. Thus, by taking a lead from this subject, synthesis of potent antifungals from coumarin moiety could contribute to the development of promising antifungal. Its resemblance and structural diversity make it possible to produce an auspicious antifungal candidate. Due to the natural origin of coumarin, its presence in diversity, and their broad spectrum of pharmacological activities, it secures an important place for the researcher to investigate and develop it as a promising antifungal in future. This manuscript discusses the bioavailability of coumarin (natural secondary metabolic molecule) that has privileged scaffold for many mycologists to develop it as a broad-spectrum antifungal against several opportunistic mycoses. As a result, several different kinds of coumarin derivatives were synthesized and their antifungal properties were evaluated. This review compiles various coumarin derivatives broadly investigated for antifungal activities to understand its current status and future therapeutic scope in antifungal therapy.

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Acknowledgements

This work was supported by the Department of Biotechnology (DBT, Government of India) through Project No. BT/IN/Indo-US/Foldscope/39/2015, and JSP received a fellowship from DBT, Government of India. The authors are grateful to the National Institute of Technology (NIT), Raipur (CG), India, for providing the space and facilities.

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Prusty, J.S., Kumar, A. Coumarins: antifungal effectiveness and future therapeutic scope. Mol Divers 24, 1367–1383 (2020). https://doi.org/10.1007/s11030-019-09992-x

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