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Molecular Diversity

, Volume 21, Issue 1, pp 1–8 | Cite as

Iodine-mediated \({ sp}^{3}\) C–H functionalization of methyl ketones: a one-pot synthesis of functionalized indolizines via the 1,3-dipolar cycloaddition reaction between pyridinium ylides and ynones

  • Issa Yavari
  • Jamil Sheykhahmadi
  • Maryam Naeimabadi
  • Mohammad Reza Halvagar
Original Article

Abstract

An efficient transition-metal-free approach toward C–H bond activation by using molecular \(\hbox {I}_{2}\)-mediated \({ sp}^{3}\) C–H bond functionalization for the synthesis of indolizine derivatives via 1,3-dipolar cycloaddition reaction of nitrogen ylides with ynones is described.

Graphical Abstract

Keywords

C–H activation 1, 3-Dipolar cycloaddition N-ylides Indolizines Iodine Ynones 

Supplementary material

11030_2016_9720_MOESM1_ESM.doc (3.2 mb)
Supplementary material 1 (doc 3304 KB)

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Issa Yavari
    • 1
  • Jamil Sheykhahmadi
    • 1
  • Maryam Naeimabadi
    • 1
  • Mohammad Reza Halvagar
    • 2
  1. 1.Department of ChemistryTarbiat Modares UniversityTehranIran
  2. 2.Department of Inorganic ChemistryChemistry and Chemical Engineering Research Center of IranTehranIran

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