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Molecular Diversity

, Volume 20, Issue 3, pp 605–610 | Cite as

Combinatorial synthesis of deuterium-enriched (S)-oxybutynin

  • Feng Li
  • Wenfeng Jiang
  • Anthony W. Czarnik
  • Wenbao Li
Original Article
  • 196 Downloads

Abstract

The concept of deuterium enrichment has gained more attention due to its advantages in the studies of clinical pharmacokinetics and metabolic profiles. In addition, it is cost and time efficient to develop deuterium-enriched drugs. Herein we built a combinatorial library of deuterated (S)-oxybutynins which all 8 D-compounds were characterized by MS, \(^{1}\hbox {H}\) NMR and \(^{ 13}\)C NMR.

Keywords

Deuterium Oxybutynin Combinatorial chemistry  Derivatives 

Supplementary material

11030_2016_9660_MOESM1_ESM.docx (2.5 mb)
Supplementary material 1 (docx 2546 KB)

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.School of Medicine and PharmacyOcean University of ChinaQingdaoPeople’s Republic of China
  2. 2.Marine Biomedical Research Institute of QingdaoQingdaoPeople’s Republic of China
  3. 3.Department of ChemistryUniversity of Nevada, RenoRenoUSA

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