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Combinatorial synthesis of deuterium-enriched (S)-oxybutynin

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Abstract

The concept of deuterium enrichment has gained more attention due to its advantages in the studies of clinical pharmacokinetics and metabolic profiles. In addition, it is cost and time efficient to develop deuterium-enriched drugs. Herein we built a combinatorial library of deuterated (S)-oxybutynins which all 8 D-compounds were characterized by MS, \(^{1}\hbox {H}\) NMR and \(^{ 13}\)C NMR.

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Authors and Affiliations

  1. School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Feng Li, Wenfeng Jiang & Wenbao Li

  2. Marine Biomedical Research Institute of Qingdao, Qingdao, 266073, People’s Republic of China

    Feng Li, Wenfeng Jiang & Wenbao Li

  3. Department of Chemistry, University of Nevada, Reno, Reno, 89557-0216, USA

    Anthony W. Czarnik

Authors
  1. Feng Li
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  2. Wenfeng Jiang
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  3. Anthony W. Czarnik
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  4. Wenbao Li
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Correspondence to Anthony W. Czarnik or Wenbao Li.

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Li, F., Jiang, W., Czarnik, A.W. et al. Combinatorial synthesis of deuterium-enriched (S)-oxybutynin. Mol Divers 20, 605–610 (2016). https://doi.org/10.1007/s11030-016-9660-4

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  • DOI: https://doi.org/10.1007/s11030-016-9660-4

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