Molecular Diversity

, Volume 20, Issue 1, pp 1–7 | Cite as

Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde

  • Pavlo A. Sokolyuk
  • Ivan S. Kondratov
  • Olexiy V. Gavrylenko
  • Andrey A. Tolmachov
Full-Length Paper


A series of pyrazole-4-sulfonyl chlorides was obtained by a convenient 2-step method starting from synthetically available 2-(benzylthio)malonaldehyde. The method can be applied for the effective multi-gram synthesis of diverse pyrazole-containing sulfonyl chlorides which are mostly not available by other methods.


Heterocycles Pyrazole Sulfonyl chlorides Sulfonamides Oxidation Chlorination Cyclization Hydrazines 



We express our appreciation to Dr. S. I. Vdovenko and O. A. Fedorenko (Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences, Ukraine) for measuring the IR-spectra.

Supplementary material

11030_2015_9633_MOESM1_ESM.doc (4.5 mb)
Supplementary material 1 (doc 4568 KB)


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Pavlo A. Sokolyuk
    • 1
    • 2
  • Ivan S. Kondratov
    • 2
    • 3
  • Olexiy V. Gavrylenko
    • 1
    • 2
  • Andrey A. Tolmachov
    • 1
    • 2
  1. 1.Kyiv National Taras Shevchenko UniversityKyiv, 33Ukraine
  2. 2.Enamine Ltd.KyivUkraine
  3. 3.Institute of Bioorganic Chemistry and PetrochemistryNational Ukrainian Academy of ScienceKyiv, 94Ukraine

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