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Molecular Diversity

, Volume 17, Issue 1, pp 9–18 | Cite as

The base-free chemoselective ring opening of epoxides with carboxylic acids using [bmim]Br: a rapid entry into 1,2-diol mono-esters synthesis

  • Mohammad Navid Soltani Rad
  • Somayeh Behrouz
Full-Length Paper

Abstract

A facile and highly convenient base-free protocol for the chemoselective preparation of 1,2-diol mono-esters is described. In this method, the regioselective ring opening of epoxides with carboxylic acids in the presence of [bmim]Br furnishes the corresponding 1,2-diol mono-esters in excellent yields. This method is efficient for various structurally diverse epoxides and carboxylic acids and it can be efficiently applied for the scale up synthesis of 1,2-diol mono-esters in reasonable to good yields. [bmim]Br remarkably influences the reaction progress and acts as both solvent and catalyst in this protocol.

Keywords

Ionic liquids [bmim]Br Epoxides Carboxylic acids 1,2-Diol mono-esters 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of ChemistryShiraz University of TechnologyShirazIran

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