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Molecular Diversity

, Volume 13, Issue 3, pp 295–300 | Cite as

A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate

  • Issa Yavari
  • Zinatossadat Hossaini
  • Maryam Sabbaghan
  • Majid Ghazanfarpour-Darjani
Full Length Paper

Abstract

An efficient one-pot synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates using acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate is described.

Keywords

Thiazole Hantzsch synthesis Ethyl bromopyruvate Aroylisothiocyanate Secondary amine 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Issa Yavari
    • 1
  • Zinatossadat Hossaini
    • 1
  • Maryam Sabbaghan
    • 2
  • Majid Ghazanfarpour-Darjani
    • 1
  1. 1.Chemistry DepartmentTarbiat Modares UniversityTehranIran
  2. 2.Chemistry DepartmentShahid Rajaee Teacher Training UniversityTehranIran

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