Molecular Diversity

, Volume 9, Issue 4, pp 353–359 | Cite as

Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison

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Reactions using fluorous reagents and scavengers are compared side-by-side with their solid-supported counterparts. Fluorous triphenylphosphine is used in the bromination reaction of alcohols, fluorous thiol is used as an electrophile scavenger for α-bromoketones, fluorous isatoic anhydride is used as a nucleophile scavenger for primary and secondary amines. Reactions involving fluorous reagents and scavengers occur in homogeneous media with solution-phase reaction kinetics. Reactions with solid-supported reagents and scavengers occur in a heterogeneous media, and the reaction kinetics are greatly affected by the nature of the solid-support and reaction environment. Significantly larger amounts of reagents and more time are usually required to complete the solid-supported reaction.

Key Words

fluorous reagents fluorous scavengers isatoic anhydride reaction kinetics reaction rate solid-supported reagents solid-supported scavengers thiol triphenylphosphine 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Fluorous TechnologiesInc. University of Pittsburgh Applied Research CenterPittsburghUSA

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