We present the advantages and features of comprehensive application of atomic force microscopy, laser interference microscopy, and Raman microscopy to study erythrocytes. We have determined the effectiveness of signal enhancement as a function of the size of silver nanoparticles in the Raman method. We consider the feasibility of using the developed techniques for clinical diagnosis.
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This work was done with the financial support from the Ministry of Education and Science of the Russian Federation (State Contract No. 16.552.11.7049).
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Translated from Metrologiya, No. 5, pp. 40–45, May, 2012.
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Maksimov, G.V., Braze, N.A., Yusipovich, A.I. et al. Use of nanoparticles for studying hemoglobin. Meas Tech 55, 731–733 (2012). https://doi.org/10.1007/s11018-012-0029-5
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DOI: https://doi.org/10.1007/s11018-012-0029-5